Prehabilitation for Cirrhosis of the Liver
Prehabilitation for Patients Awaiting Liver Transplantation
See full descriptionAbout the trial for Cirrhosis of the Liver
Treatment Groups
This trial involves 2 different treatments. Prehabilitation is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
About The Treatment
Eligibility
This trial is for patients born any sex aged 18 and older. There are 3 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Prehabilitation will improve 1 primary outcome and 4 secondary outcomes in patients with Cirrhosis of the Liver. Measurement will happen over the course of 24 weeks.
Who is running the study
Principal InvestigatorPatient Q & A Section
What is cirrhosis of the liver?
cirrhosis of the liver is a serious and irreversible disease that typically develops in people over age 40. It occurs when there is long-term damage to the liver’s parenchymal cells, blood vessels and function as a result of an underlying cause such as alcohol, viral, or other toxins.
What causes cirrhosis of the liver?
The cause of cirrhosis in the majority of cases is unknown. Risk factors for developing cirrhosis include alcoholism, excessive use of alcohol as a food supplements, and diabetes. Cirrhosis is reversible by stopping alcohol use or starting a program to regain normal liver function.
Can cirrhosis of the liver be cured?
Currently there is no cure for cirrhosis of the liver. With appropriate management and liver transplantation if necessary, it is possible to improve a patient's prognosis dramatically.
What are common treatments for cirrhosis of the liver?
Treatment of hepatic fibrosis can be done using different approaches which can be summarized into four main strategies (therapeutic options): interventional (i.e., liver transplantation), medical (i.e., antifibrotic drugs), interventional (i.e., radiofrequency ablation (RFA), transjugular intrahepatic portosystemic shunt (TIPS, a shunt between the portal vein and the systemic venous system, or a surgical shunting operation), and supportive therapeutic options (i.e.
How many people get cirrhosis of the liver a year in the United States?
An estimated 8% of Americans ≥ 65 years of age will develop cirrhosis of the liver during their lifetimes (i.e., an expected prevalence of 1% of men and 3% of women). However, the disease remains grossly under-diagnosed. A number of approaches, including education, public health, and research, are needed to enhance the care of persons with cirrhosis of the liver and ultimately optimize quality of life and patient outcomes.
What are the signs of cirrhosis of the liver?
A few of the early signs and symptoms of cirrhosis of the liver and its complications are fatigue, loss of appetite, itchiness, dry skin and abdominal pain. The hallmark of cirrhosis, portal hypertension can cause a painful liver problem in most people.
How does prehabilitation work?
Results from a recent paper of the present study indicate that prehabilitation improved exercise capacity and muscle strength in patients and reduced the amount of time required for rehabilitation, which was particularly beneficial for patients with cirrhosis or chronic obstructive pulmonary disease. Therefore, prehabilitation should be included in prehospital strategies to improve the outcome of patients.
Does prehabilitation improve quality of life for those with cirrhosis of the liver?
Results imply that physical rehabilitation before liver [transplant](https://www.withpower.com/clinical-trials/transplant)ation is a beneficial intervention for patients, and that it may have positive effects on QOL and symptoms. Prospective randomized trials with large samples would be very valuable in assessing the value of preoperative rehabilitation with respect to benefits on QOL.
What is the average age someone gets cirrhosis of the liver?
Approximately 85% of patients on medical home teams with chronic liver disease (CLD) were ≥65 when they received the diagnosis of CLD. These data provide important information for providers and health planners, including a broader spectrum of patients in whom chronic liver disease management is being discussed.
Does cirrhosis of the liver run in families?
There is no evidence that cirrhosis runs in families. Genetic predisposition may occur in only some of cases of cirrhosis, and in this case one should not assume there is a "familial" component.
Who should consider clinical trials for cirrhosis of the liver?
For cirrhosis treatment, clinical trials can provide the best option because it can compare different products against one another and compare with or without active treatment.
What are the common side effects of prehabilitation?
This survey of prehabilitation side effects suggests that many patients experience significant side effects from prehabilitation, particularly if they are using a nebulizer. This information can help improve the overall management of patients who are prepped with prehabilitation. With further research, the types and severity of medications used in this setting should be studied.