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Intensive Medical Management Group - no CAS for Carotid Stenosis (C2LOE Trial)

N/A
Waitlist Available
Led By James Meschia, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights

C2LOE Trial Summary

The purpose of this Long-Term Observational Extension of Participants in the CREST-2 Randomized Clinical Trial (C2LOE - ClinicalTrials.gov Identifier: NCT02089217) study is to study is to assess post-procedural efficacy of carotid endarterectomy and carotid stenting.

Eligible Conditions
  • Carotid Stenosis

C2LOE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Stroke

C2LOE Trial Design

4Treatment groups
Experimental Treatment
Group I: Intensive Medical Management Group - no CEAExperimental Treatment1 Intervention
Subjects assigned to the intensive medical management alone with no carotid endarterectomy (CEA) group in the CREST-2 study (NCT02089217)
Group II: Intensive Medical Management Group - no CASExperimental Treatment1 Intervention
Subjects assigned to the intensive medical management alone with no carotid stenting (CAS) group in the CREST-2 study (NCT02089217)
Group III: Carotid Stenting Group (CAS)Experimental Treatment2 Interventions
Subjects assigned to the intensive medical management with carotid stenting group in the CREST-2 study (NCT02089217)
Group IV: Carotid Endarterectomy Group (CEA)Experimental Treatment2 Interventions
Subjects assigned to the intensive medical management with carotid endarterectomy group in the CREST-2 study (NCT02089217)

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,253 Previous Clinical Trials
3,832,951 Total Patients Enrolled
5 Trials studying Carotid Stenosis
5,855 Patients Enrolled for Carotid Stenosis
University of Alabama at BirminghamOTHER
1,598 Previous Clinical Trials
2,284,282 Total Patients Enrolled
2 Trials studying Carotid Stenosis
2,887 Patients Enrolled for Carotid Stenosis
Medical University of South CarolinaOTHER
947 Previous Clinical Trials
7,395,588 Total Patients Enrolled
~1153 spots leftby Feb 2026
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