Respiratory Viruses for Blood Cancers
(RV-BOS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if respiratory viruses cause lung disease in individuals who have received a donor stem cell transplant. The primary focus is on bronchiolitis obliterans syndrome (BOS), a lung condition that can develop after a transplant. Participants will use a simple handheld device for spirometry (a test to measure lung function) at home, potentially aiding in the earlier diagnosis and treatment of lung issues. Individuals who have had a donor stem cell transplant and are at risk for BOS, particularly those who have experienced graft-versus-host disease or recent lung infections, may be suitable for this trial. Participants need a smartphone to share their health data electronically.
As an unphased trial, this study provides a unique opportunity for participants to contribute to groundbreaking research that could lead to earlier diagnosis and treatment of lung issues post-transplant.
Do I need to stop my current medications to join the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that spirometry is safe for monitoring lung function at home?
Research shows that spirometry is a safe and easy procedure. It measures lung function using a small handheld device. Studies have found it to be generally safe, although some people might feel slightly short of breath or dizzy immediately after the test. This is normal and usually resolves quickly. Spirometry has been used for many years in various health programs, proving it is a reliable and safe method for checking lung health.12345
Why are researchers excited about this trial?
Researchers are excited about this trial because it explores the use of home spirometry to monitor respiratory health in patients with Bronchiolitis Obliterans Syndrome after a stem cell transplant. Unlike traditional methods that require frequent hospital visits, this approach uses a portable handheld spirometer, allowing patients to perform lung function tests conveniently at home. This could lead to earlier detection of issues, more personalized treatment plans, and ultimately, improved outcomes for patients. Additionally, regular nasal swabs and blood collections help track viral infections, which could provide insights into preventing or managing complications.
What evidence suggests that spirometry is effective for monitoring lung function in patients with BOS?
Research shows that spirometry, a simple breathing test, helps track lung health and diagnose lung infections. Studies have found that spirometry can identify breathing problems in individuals who have experienced illnesses like COVID-19. By revealing changes in lung performance, it helps detect lung issues early. In this trial, participants will use a handheld spirometer for home spirometry measurements, potentially identifying diseases like bronchiolitis obliterans syndrome (a type of lung disease) sooner. This is particularly important for patients who have received a donor stem cell transplant and are at risk for lung problems.678910
Who Is on the Research Team?
Guang-Shing Cheng, MD
Principal Investigator
Fred Hutch/University of Washington Cancer Consortium
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Observation
Participants undergo home spirometry measurements with a portable handheld spirometer and complete questionnaires weekly, a nasal swab for viral PCR surveillance every 4 weeks, and undergo blood collection and nasal swabs every 3 months
Follow-up
Participants are monitored for the incidence of late onset noninfectious pulmonary complications and other outcomes
What Are the Treatments Tested in This Trial?
Interventions
- Respiratory Virus Testing
- Spirometry
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients undergo home spirometry measurements with a portable handheld spirometer and complete questionnaires weekly, a nasal swab for viral polymerase chain reaction (PCR) surveillance every 4 weeks, and undergo blood collection and nasal swabs every 3 months for up to 2 years.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Fred Hutchinson Cancer Center
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Citations
Clinical features and outcomes of viral respiratory infections in ...
In this context, our study aimed to compare the clinical characteristics and hospitalization risks associated with the major respiratory viruses ...
Post-discharge spirometry evaluation in patients ...
This study highlights that patients recovering from moderate-to-critical COVID-19 often exhibit abnormal spirometry, notably a restrictive pattern and PRISm.
Respiratory viral infections: when and where? A scoping ...
Respiratory viral infections pose a substantial disease burden worldwide. Spatiotemporal techniques help identify transmission patterns of these ...
What diagnostic tests are available for respiratory ...
Spirometry tests, indicating lung function, facilitate respiratory infection diagnoses. There is no clear definition of what an exacerbation is in persons with ...
How spirometry can help manage lung infections
Spirometry can be a valuable tool in managing lung infections, by providing detailed information on lung function and tracking a patient's ...
Spirometry Testing in Occupational Health Programs
OSHA standards for asbestos, cadmium, coke oven emissions, and cotton dust require spirometry testing as part of medical surveillance. (see 29 CFR 1910.1001, ...
Safety of pulmonary function testing: data from 20 years
Routine and specialised PFT is safe for patients, in the context of established screening preparticipation guidelines.
HHE Report No. HETA-2008-0155-3131, Lung Function ( ...
They should have follow up spirometry testing at 3 month intervals at least until their lung function has stabilized.
Spirometry
Spirometry is generally a safe test. You may feel short of breath or dizzy for a moment after you do the test. Because the test requires some ...
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acoem.org
acoem.org/acoem/media/PDF-Library/Publications/Spirometry_in_Occupational_Health_2020-15-%282%29.pdfSpirometry in Occupational Health—2020 - ACOEM
Longitudinal evaluations of peri- odic spirometry testing may detect exces- sive lung function loss due to an exposure or underlying condition ...
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