Dietary Intervention for Breast Cancer Risk Reduction
(LIN-BRiCK Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, it mentions that changes in anti-hyperglycemic or lipid-lowering medications should be avoided unless necessary. You can continue using endocrine therapy, but you cannot change the dose or schedule during the study.
What data supports the effectiveness of the low-insulinemic dietary intervention treatment for breast cancer risk reduction?
The research indicates that diets with high glycemic index (GI) and glycemic load (GL) are not associated with an increased risk of breast cancer in postmenopausal women, suggesting that a low-insulinemic diet, which focuses on low GI and GL foods, may not increase breast cancer risk. However, the studies do not provide direct evidence that such a diet reduces breast cancer risk.12345
Is a low-glycemic diet safe for humans?
How does the Low-Insulinemic Dietary Intervention treatment for breast cancer risk reduction differ from other treatments?
The Low-Insulinemic Dietary Intervention is unique because it focuses on reducing insulin levels by consuming foods with a low glycemic index (which measure how quickly foods raise blood sugar levels), potentially influencing insulin-like growth factor levels linked to breast cancer risk. Unlike traditional treatments that may involve medication or surgery, this approach uses dietary changes to address risk factors associated with breast cancer.1241011
What is the purpose of this trial?
This clinical trial tests whether a new dietary pattern that consists of foods that lower the blood insulin response can reduce breast cancer risk in high-risk women. In a large group of patients, this new dietary pattern was associated with reduced risk of multiple cancers and reduced risk of long-term weight gain. Parts of this new dietary pattern are quite different from typical dietary recommendations, and much education is needed. Overall, compared to the typical American diet, this new dietary pattern is moderately low in total fat and saturated fat, low in protein from animal foods but high in protein from plant sources, high in fruits and vegetables, high in whole grains, and high in dietary fiber. We will determine if a low-insulinemic dietary pattern intervention is feasible and effective in reducing breast cancer risk in high-risk women.
Research Team
Fred K Tabung, PhD, MSPH
Principal Investigator
Ohio State University Comprehensive Cancer Center
Eligibility Criteria
This trial is for high-risk women who may benefit from a new diet aimed at reducing breast cancer risk. The diet focuses on lowering blood insulin levels and includes plant proteins, fruits, vegetables, whole grains, and dietary fiber while being low in animal proteins and fats.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Dietary Intervention
Participants receive the low-EDIH dietary pattern intervention consisting of 6 group nutrition education sessions and 3 individual counseling sessions.
Follow-up
Participants are monitored for safety and effectiveness after the dietary intervention
Treatment Details
Interventions
- Low-Insulinemic Dietary Intervention
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ohio State University Comprehensive Cancer Center
Lead Sponsor
American Cancer Society, Inc.
Collaborator