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Behavioural Intervention
Cognitive Demands and Electrical Stimulation in Memory Function Research
N/A
Recruiting
Led By Joel Voss, PhD
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up outcome assessed 5 minutes after intervention
Awards & highlights
Study Summary
This trial tests how the hippocampus helps form memories by influencing how we look at things. It'll measure and manipulate activity in the hippocampus, and use direct electrical stimulation to test its role in helping us remember.
Who is the study for?
This study is for adults over 18 with normal or corrected vision who speak English natively. It's designed for individuals with epilepsy undergoing neurosurgical procedures, allowing researchers to record and stimulate brain activity directly.Check my eligibility
What is being tested?
The trial investigates how the hippocampus influences memory formation and visual processing. Participants will perform eye-tracking tasks while receiving different cognitive challenges and electrical stimulations to their brains.See study design
What are the potential side effects?
Since this research involves people already in clinical care for epilepsy, side effects are related to standard risks of iEEG such as discomfort at electrode sites, potential infection risk, and possible transient impact on memory or attention.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ outcome assessed 5 minutes after intervention
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~outcome assessed 5 minutes after intervention
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
iEEG phase synchrony to eye movement
iEEG theta band power
Secondary outcome measures
Eye movements
Memory task performance
Trial Design
6Treatment groups
Experimental Treatment
Group I: Experiment 6Experimental Treatment1 Intervention
The same group of 20 iEEG subjects that are included in Study Experiment Condition 5 will perform the same eye-tracking memory task as described for Study Experiment Condition 2. This experiment condition will be performed on a different day of the inpatient visit than participation in Study Experiment Condition 5.
Group II: Experiment 5Experimental Treatment1 Intervention
Subjects with iEEG electrodes implanted will perform the same eye-tracking memory task as described for Study Experiment Condition 1. This is a different group of iEEG subjects selected based on having iEEG electrodes implanted in the hippocampus as well as in at least one location of the Dorsal Attention Network (DAN), which is a region of interest for the experiment condition. 20 subjects undergoing iEEG recordings as part of epilepsy treatment will be assigned to this study experiment condition.
Group III: Experiment 4Experimental Treatment2 Interventions
The same 20 subjects with iEEG electrodes implanted who perform Study Experiment Condition 1 will perform the same eye-tracking memory task described for Study Experiment Condition 2. For these subjects, high-frequency electrical stimulation will be delivered through the iEEG electrodes on a subset of study trials, with half of stimulated trials receiving stimulation of the hippocampus and the other half receiving stimulation of the amygdala. This memory task will take about 1.5 hours to complete and will be performed on a different day of their inpatient visit than the procedures for Study Experiment Condition 1.
Group IV: Experiment 3Experimental Treatment2 Interventions
The same 20 subjects with iEEG electrodes implanted who perform Study Experiment Condition 2 will perform the same eye-tracking memory task described for Study Experiment Condition 1. For these subjects, high-frequency electrical stimulation will be delivered through the iEEG electrodes on a subset of study trials, with half of stimulated trials receiving stimulation of the hippocampus and the other half receiving stimulation of the amygdala. This memory task will take about 1.5 hours to complete and will be performed on a different day of their inpatient visit than the procedures for Study Experiment Condition 2.
Group V: Experiment 2Experimental Treatment1 Intervention
Subjects with iEEG electrodes implanted will perform an eye-tracking memory task in which they view arrays of everyday objects arranged as a grid and later undergo memory testing for these object image arrays. Half of the object-image arrays are studied actively (subjects view objects in any order they wish) and half are studied passively (viewing patterns are predetermined and subjects must follow along). For the memory test, subjects attempt to pick studied objects from among novel (foil) objects and replace them at studied locations using the computer mouse. Eye movements will be remotely (noninvasively) tracked using a camera during the study phases. This memory task will take about 1.5 hours to complete. 20 subjects undergoing iEEG recordings as part of epilepsy treatment will be assigned to this study experiment condition.
Group VI: Experiment 1Experimental Treatment1 Intervention
Subjects with iEEG electrodes implanted will perform an eye-tracking memory task in which they view pictures of naturalistic scenes and later undergo memory testing for these scene pictures. For the memory test, studied scenes will be repeated and presented along with novel (foil) scenes. Subjects will attempt to discriminate studied from novel scenes using button press responses. Eye movements will be remotely (noninvasively) tracked using a camera during both study and test. This memory task will take about 1.5 hours to complete. 20 subjects undergoing iEEG recordings as part of epilepsy treatment will be assigned to this study experiment condition.
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Who is running the clinical trial?
University of ChicagoLead Sponsor
1,004 Previous Clinical Trials
819,711 Total Patients Enrolled
National Institute of Mental Health (NIMH)NIH
2,786 Previous Clinical Trials
2,689,643 Total Patients Enrolled
Joel Voss, PhDPrincipal InvestigatorUniversity of Chicago
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am a native English speaker.I am 18 years old or older.My vision is normal or corrected to normal.
Research Study Groups:
This trial has the following groups:- Group 1: Experiment 2
- Group 2: Experiment 1
- Group 3: Experiment 3
- Group 4: Experiment 4
- Group 5: Experiment 5
- Group 6: Experiment 6
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Does this trial include participants who are twenty years or older?
"The present trial is targeting individuals aged 18-45."
Answered by AI
What is the uppermost boundary for enrollment in this clinical experiment?
"Affirmative. According to clinicaltrials.gov, this medical trial is still in the recruitment phase and was initially published on January 16th 2023. It has since been modified on July 7th 2023 and requires 66 subjects from 2 separate sites for full participation."
Answered by AI
Do I qualify to register for this research trial?
"This medical trial seeks 66 participants who possess a basic understanding of hippocampal memory and are between 18 to 45 years old."
Answered by AI
Are there any recruitment opportunities for this scientific trial?
"Affirmative. Clinicaltrials.gov hosts data that shows this scientific examination, which was originally launched on January 16th 2023, is currently recruiting participants. 66 individuals are needed to participate across 2 different medical centres."
Answered by AI
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