Intermittent Theta-Burst Stimulation for ADHD
(ACHIEVE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Impaired inhibitory response manifests clinically as increased impulsivity, which leads to poorer affective, cognitive, social, and occupational functioning. Neuropsychiatric disorders prevalent among Veterans, such as Attention Deficit/Hyperactivity Disorder (ADHD), are associated with poor inhibitory control. The mainstay of clinical treatment for ADHD is psychostimulants, yet these medications have significant risks, including dependence and numerous side effects. Thus, novel and non-pharmacological therapeutic strategies are needed. Intermittent Theta Burst Stimulation, a newer form of transcranial magnetic stimulation, has emerged as a promising tool for modulating inhibitory neuronal circuits. This research proposal will investigate the feasibility and acceptability of iTBS on inhibitory control and impulsivity through a randomized controlled trial to inform clinical observations. The long-term goal is to improve impulsivity, social and occupational functioning, and enhance the quality of life for Veterans.
Who Is on the Research Team?
Camila Souza A Cosmo, PhD
Principal Investigator
Providence VA Medical Center, Providence, RI
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive iTBS treatment targeting inhibitory control with active or sham stimulation sessions
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessment of impulsivity and social/occupational functioning
What Are the Treatments Tested in This Trial?
Interventions
- Intermittent Theta Burst Stimulation
How Is the Trial Designed?
2
Treatment groups
Active Control
Placebo Group
Active iTBS includes two extended stimulation sessions, at 90% MT, with standard parameters (50Hz triplets every 200ms), each consisting of 3,600 pulses (19 minutes), with a 30-minute intersession interval.
Sham will be administered using equivalent procedures but with a sham coil. The sham coil is specifically designed to match the active coil in appearance, sound, and scalp sensation, providing a credible sham experience, as observed in our prior studies.
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor
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