Real-time asthma care outreach for Asthma

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Kaiser Permanente Southern California Region, San Diego, CA
Asthma
Real-time asthma care outreach - Other
Eligibility
< 65
All Sexes
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Study Summary

This study is evaluating whether real-time identification of uncontrolled asthma leads to better asthma control.

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Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Real-time asthma care outreach will improve 2 primary outcomes and 2 secondary outcomes in patients with Asthma. Measurement will happen over the course of 1 year.

1 year
Frequency of patients with documented step-up care.
Frequency, characteristics, and exacerbations of patients placed on omalizumab therapy
Oral corticosteroid courses for asthma exacerbations in risk cohort.
Short-acting beta-agonist dispensings.

Trial Safety

Trial Design

2 Treatment Groups

Usual care
1 of 2
Real-time asthma care outreach
1 of 2
Active Control
Experimental Treatment

This trial requires 3000 total participants across 2 different treatment groups

This trial involves 2 different treatments. Real-time Asthma Care Outreach is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Real-time asthma care outreach
Other
Usual care

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 1 year
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 1 year for reporting.

Who is running the study

Principal Investigator
R. S. Z.
Robert S. Zeiger,, MD PhD
Kaiser Permanente

Closest Location

Kaiser Permanente Southern California Region - San Diego, CA

Eligibility Criteria

This trial is for patients born any sex aged 65 and younger. There are 5 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
12-56 years of age
Continuously enrolled and with pharmacy benefit for the past year
Dispensed inhaled corticosteroid (ICS) in the past 6 months.
Uncontrolled asthma: defined within the past year
Impairment cohort: 7th short-acting beta-agonist (SABA) canister dispensed and/or Risk (exacerbation) cohort: 2nd oral corticosteroid (OCS)dispensing with provider asthma exacerbation encounter within 2 days and at least 1 month after the first OCS dispensing.

Patient Q&A Section

What are common treatments for asthma?

"The majority of patients use medication to control or reduce asthma. Some treatments are unique to certain patient groups, such as the anti-inflammatory and/or corticosteroid sprayers. Also some treatments can be used to treat both asthma and COPD (which itself is a type of asthma). However, a small minority of patients do not use prescribed medications. Those who do do so less frequently than those who do not. Some of the treatments are different to those in other asthma disease. For those who do not have a controller medication, the recommended treatment is the aforementioned (above) inhaler (an inhaled corticosteroid, usually for at least six months)." - Anonymous Online Contributor

Unverified Answer

What causes asthma?

"Asthma can occur in individuals without a previous history of airway disease or in the presence of an underlying autoimmune disease. The triggers for sensitisation and bronchial hyperreactivity are varied. Aspects of the environment of the developing fetus, particularly air pollution, tobacco smoke, or [allergy](https://www.withpower.com/clinical-trials/allergy)-causing agents including house dust mites, could all be involved. Once sensitisation occurs, there are a number of pathological alterations that include epithelial atrophy and fibrosis, smooth muscle hyperreactivity, and T-cell activation." - Anonymous Online Contributor

Unverified Answer

How many people get asthma a year in the United States?

"An average of 2.9 million (≈1 in 28) people per year received an asthma diagnosis. The estimated incidence of asthma has been estimated at approximately 1 in 15. These numbers were found among those aged 18 years and ≥20 years but the incidence rates were higher among those aged 10-15 years." - Anonymous Online Contributor

Unverified Answer

What are the signs of asthma?

"Asthma can be diagnosed in primary care from the symptoms described above. The clinical examination is of little value. If there are associated features, such as excessive smoking, one can give the diagnosis to patients without clinical examination." - Anonymous Online Contributor

Unverified Answer

Can asthma be cured?

"Results from a recent clinical trial, patients reported dramatic change in the health status and quality of life. It’s important to assess asthma outcomes and patient-reported benefits in other studies." - Anonymous Online Contributor

Unverified Answer

What is asthma?

"Symptoms of asthma are recurrent wheezing, coughing and decreased exercise tolerance. People with asthma are at increased risk of developing lower respiratory tract infections, of a more severe nature and of a more protracted course, in comparison with the general population. The prognosis of asthma is generally determined by the amount and ease of symptoms it causes." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating asthma?

"There is still a need to further evaluate the efficacy of multiple new medications for the treatment of asthma, and a need for more well-controlled trials of treatments that are already effective (see guideline recommendations). Some of the possibilities for consideration include the use of budesonide (Rynatan); the use of olopatadine (Lunaris) either as monotherapy or in combination with formoterol (Symbicort); and the potential role of omalizumab (Xolair)." - Anonymous Online Contributor

Unverified Answer

Does real-time asthma care outreach improve quality of life for those with asthma?

"Asthma outpatient and preventive services were effective at achieving improvements in health status. Further expansion and evaluation of these services, with a broad view of patient health needs, is feasible and may be associated with a significant improvement in asthma quality of life." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of asthma?

"The strongest association between respiratory infections and asthma development was a respiratory infection prior to the age of 5 years. The risk of developing asthma increased with cumulative severity of infection episodes and duration of infection episodes. However, asthma development was not associated with an increased risk of bronchiolitis." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in real-time asthma care outreach for therapeutic use?

"Real-time electronic medical records, advanced clinical protocols, and use of electronic documentation systems are key elements in facilitating a safe, convenient and efficient transition for the managing of a pediatric patient with asthma. This transition is likely to benefit patients with asthma, their parents and care providers, clinicians and support staff and other stakeholders." - Anonymous Online Contributor

Unverified Answer

Is real-time asthma care outreach typically used in combination with any other treatments?

"The study has shown very few asthma patients are referred to an A&E department for immediate, individual, asthma care, although a sizeable proportion of patients were referred to an A&E department, probably as part of a package of care. Most patients were referred to a primary care GP, whose role may vary and may not always include advice on all aspects of asthma management. The provision of asthma care advice as part of an asthma care package does not appear to be common in GP systems for reasons that remain unclear. Many patients did not receive bronchial-constricting agents, only when necessary for patients who were admitted to the A&E department." - Anonymous Online Contributor

Unverified Answer

What is real-time asthma care outreach?

"The authors' model of real-time asthma outreach provided a novel, evidence-based, resource-efficient, and efficient method for facilitating rapid management of asthma. This model's potential for widespread application is supported by its ability to quickly and permanently change the way asthma care is delivered throughout the community." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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