MRI for Dental Anesthesia
(MRI and LA Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how a special type of MRI, called ddMRI, can visualize the effects of dental anesthesia. Researchers aim to use MRI to observe the distribution and effectiveness of anesthesia in the mouth. This study seeks to improve understanding of anesthesia's effectiveness during dental procedures. Healthy individuals who can attend in-person sessions and have had no recent dental trauma might be suitable candidates for this trial. As an unphased study, this trial offers a unique opportunity to contribute to innovative research that could enhance dental care.
What prior data suggests that this MRI technique is safe for dental patients?
Studies have shown that a special type of MRI, called dental-dedicated MRI (ddMRI), effectively visualizes the distribution of local anesthesia in the mouth. This MRI is safe and functions similarly to a regular MRI by capturing images.
Research indicates that local anesthesia in dentistry is very safe when administered by trained professionals, such as dental hygienists. Common drugs like lidocaine and articaine have a strong safety record. These drugs are widely used and considered among the safest options for dental procedures. However, excessive doses can cause issues like dizziness or a racing heart, so following recommended doses is crucial.
Overall, existing research confirms the safety of both ddMRI and local anesthesia. The MRI assists doctors in assessing the effectiveness of the anesthesia.12345Why are researchers excited about this trial?
Researchers are excited about the MRI for dental anesthesia trial because it offers a new way to visualize how local anesthetics spread and work in the mouth. Unlike traditional methods, which rely on patient feedback and clinical judgment, the ddMRI technique provides a detailed image of anesthetic distribution and intensity. This could lead to more precise and effective dental procedures, reducing discomfort and improving outcomes for patients. By directly observing how anesthesia behaves, dentists might tailor treatments better, enhancing both safety and efficiency.
What evidence suggests that ddMRI is effective for observing dental anesthesia?
This trial will use ddMRI scanning to observe the distribution of dental anesthesia after administration. Research has shown that MRI can help doctors visualize the spread of dental anesthesia in the mouth. Although MRI doesn't relieve pain, it reveals precisely where the anesthesia travels after administration. This is crucial because the success of dental anesthesia relies on its effective delivery and distribution. Studies indicate that dental anesthesia can achieve success rates of up to 100% in some cases. Tracking anesthesia with MRI might enhance these rates by enabling doctors to refine their techniques for improved outcomes.23467
Who Is on the Research Team?
Rachel Uppgaard, DDS, FACS
Principal Investigator
University of Minnesota
Are You a Good Fit for This Trial?
This trial is for dental patients who are receiving local anesthesia and can safely undergo an MRI scan. People with conditions that make MRI unsafe, such as certain metal implants or severe claustrophobia, cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Anesthesia Administration
Local anesthesia is administered to dental patients, followed by ddMRI scanning to evaluate the distribution and intensity of the anesthetic
Immediate Evaluation
Patient reported sensation and ability to sense touch, pressure, and direction are evaluated within 1 hour of the nerve block
Follow-up
Participants are monitored for any delayed reactions or side effects after the procedure
What Are the Treatments Tested in This Trial?
Interventions
- ddMRI
Trial Overview
The study is testing whether a special type of MRI designed for dental use (ddMRI) can help doctors see how local anesthesia spreads in the mouth during dental procedures.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
The ddMRI will take place after anesthesia administration. The ddMRI will allow researchers to see and measure the distribution of the local anesthetic, as well as the the area of the local anesthetic and the intensity on MRI.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Minnesota
Lead Sponsor
Citations
Local Anesthetic Usage Among Dentists: German and ... - PMC
The aim of this study was to analyze the use of dental local anesthetics in Germany compared with international data.
Study Details | NCT07602686 | MRI and Local Anesthesia
The ddMRI will take place after anesthesia administration. The ddMRI will allow researchers to see and measure the distribution of the local anesthetic, as well ...
A narrative review on local anesthetics in dentistry
This review reinforces that the effectiveness and safety of dental anesthesia depend not only on drug selection but also on context-driven ...
Trends in Local Anesthesia Delivery
Research demonstrates that delivery via spray into the ipsilateral nostril of the treatment area achieved adequate anesthesia 84% to 90% of the ...
5.
dimensionsofdentalhygiene.com
dimensionsofdentalhygiene.com/article/research-demonstrates-the-safety-of-local-anesthesia-administration-by-dental-hygienists/Research Demonstrates the Safety of Local Anesthesia ...
An analysis of clinically active dental hygienists in Pennsylvania self-reported high success rates with local anesthesia: 95% to 100% success ...
Selection of the safest local anesthetic for dental treatment in ...
Mepivacaine, lidocaine, and articaine are among the safest agents for various systemic conditions. An evidence based, condition specific approach enhances ...
7.
decisionsindentistry.com
decisionsindentistry.com/article/update-on-maximum-local-anesthesia-dosages/Update on Maximum Local Anesthesia Dosages
The current FDA recommendation lists a 3.2 mg/lb maximum, with no absolute maximum established; however, based on the epinephrine content, there ...
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