420 Participants NeededMy employer runs this trial

PAGODA Algorithm for Gastrointestinal Cancer

Recruiting at 283 trial locations
LJ
Overseen ByLilli Johnson
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Alliance for Clinical Trials in Oncology
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This study seeks to learn whether using the PAGODA algorithm to guide chemotherapy dosing will lower the chance of unplanned delays during chemotherapy for cancer in the gastrointestinal system compared to usual care.

Who Is on the Research Team?

GA

Gabriel A. Brooks, MD, MPH

Principal Investigator

Alliance for Clinical Trials in Oncology

Are You a Good Fit for This Trial?

Inclusion Criteria

I am planning to receive at least four cycles of FOLFOX chemotherapy.
I am able to care for myself and do light activities.
ANC ≥ 1,000/mm^3
See 15 more

Exclusion Criteria

I have had systemic therapy for GI cancer, except for just one cycle of FOLFOX.
I need white blood cell growth factor with my first FOLFOX chemo due to high infection risk.
History of hypersensitivity reaction to oxaliplatin, other platinum-based drugs, fluorouracil, or leucovorin, and the excipients in their formulations
See 2 more

What Are the Treatments Tested in This Trial?

Interventions

  • Fluorouracil
  • Oxaliplatin
  • PAGODA algorithm

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Arm B- PAGODA AlgorithmExperimental Treatment4 Interventions
Group II: Arm A- Physician DiscretionActive Control3 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Alliance for Clinical Trials in Oncology

Lead Sponsor

Trials
521
Recruited
224,000+

National Cancer Institute (NCI)

Collaborator

Trials
14,080
Recruited
41,180,000+