Topical Products for Skin Aging

(Before/After Trial)

No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests four different face care products to evaluate their effectiveness in improving facial skin longevity over eight weeks. Participants will use a cream, serum, or eye cream, each containing an ingredient called Mitopure. The study aims to collect data through images and personal feedback on how these products affect skin appearance. Individuals with noticeable facial wrinkles who regularly use sunscreen may be suitable for this trial. As an unphased trial, it offers participants the chance to contribute to innovative skincare research and potentially enhance their own skin health.

Do I need to stop taking my current medications for the trial?

The trial does not specify if you need to stop taking your current medications, but you must avoid using certain facial products like moisturizers and anti-aging treatments before and during the study. It's best to discuss your specific medications with the trial team.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that Mitopure, the main ingredient in the face care products being tested, is safe for use. Many studies have found no harmful effects from Mitopure. As a type of Urolithin A, it helps protect cells and combat aging.

In some studies, daily use of creams with Mitopure did not damage the skin's outer layer. Dermatologists have also tested Mitopure and consider it safe, gentle on the skin, and unlikely to cause allergic reactions.

Overall, evidence suggests that these skin products are well-tolerated with no reported negative effects, offering reassurance about their safety.12345

Why are researchers excited about this trial's treatments?

Researchers are excited about these face care products for skin aging because they contain Mitopure, a novel ingredient not typically found in current anti-aging treatments. Unlike standard skincare options that often rely on ingredients like retinoids or hyaluronic acid, Mitopure targets cellular rejuvenation by enhancing mitochondrial function, which is thought to help improve skin vitality and reduce signs of aging. These products, offered as a cream, serum, and eye cream, provide versatile application methods, potentially catering to different skincare needs and preferences. This innovative approach could offer a fresh alternative for those seeking effective anti-aging solutions.

What evidence suggests that this trial's treatments could be effective for skin aging?

Research has shown that Mitopure, an ingredient in the face care products tested in this trial, has promising effects on skin health. Participants will use different formulations, including cream A, cream B, serum, and eye cream, each containing Mitopure. Studies have found that applying Mitopure to the skin can noticeably reduce wrinkles in just two weeks. It also increases collagen, which helps maintain skin firmness and elasticity. Additionally, research reports a 14% reduction in skin redness with Mitopure cream. Overall, these findings suggest that Mitopure can help skin look younger and remain healthy longer.45678

Who Is on the Research Team?

NK

Nalini Kaul, PhD

Principal Investigator

Princeton Consumer Research Corp.

Are You a Good Fit for This Trial?

This trial is for individuals seeking to improve facial skin longevity, specifically targeting aging and wrinkles. Participants should be interested in testing topical face care products over an eight-week period.

Inclusion Criteria

My facial wrinkles score between 3.0 and 6.0 on the Fitzpatrick scale.
Subject agrees to remove jewelry and false eye lashes before the visits
I am willing to avoid the sun or use sunscreen on my face.
See 9 more

Exclusion Criteria

Allergies or sensitivities to facial moisturizer products, similar materials or their ingredients or cosmetics
Currently participating in another clinical study or trial involving the face
I do not have HIV, AIDS, or lupus.
See 12 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants use one of four topical products containing Mitopure for eight weeks

8 weeks
3 visits (in-person) at baseline, week 4, and week 8

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Face care product
Trial Overview The study aims to test the effectiveness of four different topical products designed for facial skin care. The efficacy will be measured through image analysis and participants' self-assessment questionnaires after using the products for two months.
How Is the Trial Designed?
4Treatment groups
Experimental Treatment
Group I: Face care product (serum)Experimental Treatment1 Intervention
Group II: Face care product (eye cream)Experimental Treatment1 Intervention
Group III: Face care product (cream B)Experimental Treatment1 Intervention
Group IV: Face care product (cream A)Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Amazentis SA

Lead Sponsor

Trials
21
Recruited
1,400+

Princeton Consumer Research

Collaborator

Citations

Timeline: Mitopure® | #1 Doctor Recommended Urolithin AOptimize your cellular health with Mitopure® by Timeline, the first and only Urolithin A supplement clinically-proven to target the root causes of aging.
Topical application of Urolithin A slows intrinsic skin aging ...(data not shown) nor the placebo showed a significant effect compared to the untreated control. 434. 435. Supportive Biomarkers. 436. The ...
Mitopure Reviews | Can Mitopure Slow Aging? [2025]Mitopure is a “naturally-occurring anti-aging compound” that can boost mitochondrial health, athletic performance, energy levels, and more.
(PDF) Topical application of Urolithin A slows intrinsic skin ...In the aging study 1, Urolithin A at 1% significantly up-regulated collagen synthesis pathways in human skin biopsies and led to a decrease in ...
Mitopure and Niacinamide: A Power Duo for Skin LongevityIn clinical trials, topical Mitopure visibly reduced wrinkle depth and volume in just two weeks' time. Timeline Skincare products. The Synergism ...
Urolithin AAging and related health concerns: Urolithin A may help protect against age-related diseases by preserving mitochondrial function. Mechanistically it is better ...
Efficacy of Four Topical Products to Improve Skin LongevityAlso called a data safety and monitoring board, or DSMB. ... The topical product (moisturizing formula A) containing Mitopure will be used for eight weeks.
Mitopure®: A new way to fight aging - TimelineMitopure® is dermatologist tested and approved as safe, kind to skin, and hypoallergenic. So, you can use products containing Mitopure® with ...
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