EXPAREL for Pain Relief in Knee Replacement
(CRS-121 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The study aims to test the safety and effectiveness of two different surgeon-administered methods of the anesthesia medication EXPAREL during knee replacement surgery. This study will not determine whether one method is better than the other, but will instead help the study investigator decide if both methods can provide an equal amount of pain relief.
The main question this study aims to answer is:
Will EXPAREL provide an equal amount of pain relief for patients who receive EXPAREL via Intra-articular Posteromedial Surgeon Administered (IPSA) Block and patients that receive EXPAREL via Local Infiltration Analgesia (LIA)?
Following their surgery, participants will be asked to report their pain level on their treated knee using a numerical rating scale (NRS) between 0 to 10. In addition to their pain level, participants will report any medications used for pain relief and will mark specific regions on an image to indicate where they experience pain.
Who Is on the Research Team?
Andrew I Spitzer, MD
Principal Investigator
Cedars-Sinai Medical Center
Are You a Good Fit for This Trial?
This trial is for adults 18 or older who are scheduled for knee replacement surgery due to osteoarthritis, have a BMI between 18 and 40, will get spinal anesthesia, and can follow study instructions.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Surgery and Treatment
Participants undergo knee replacement surgery and receive either the IPSA Block or Local Infiltration Analgesia (LIA) for pain management
Post-operative Monitoring
Participants report pain levels using a Numerical Rating Scale (NRS) and record any medications used for pain relief
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- EXPAREL
Trial Overview
The study compares two ways of giving the pain medication EXPAREL during knee replacement: one method injects it near the back inside part of the knee (IPSA block), while the other spreads it around the joint area (local infiltration). Both methods aim to control pain after surgery.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Group 1 will be assigned to receive the IPSA Block which is an innovative surgeon technique to administer anesthesia to a treated knee joint and will include the standard technique known as Local Infiltration Analgesia (LIA).
Group 2 will be assigned to receive Local Infiltration Analgesia (LIA) which is the standard anesthesia administration technique used for patients undergoing knee replacement surgery.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Cedars-Sinai Medical Center
Lead Sponsor
Pacira Pharmaceuticals, Inc
Industry Sponsor
Dr. Jonathan Slonin
Pacira Pharmaceuticals, Inc
Chief Medical Officer since 2020
BSc in Biomedical Engineering and MD from University of Miami, MBA from George Washington University
Frank D. Lee
Pacira Pharmaceuticals, Inc
Chief Executive Officer since 2024
BSc in Chemical Engineering from Vanderbilt University, MBA from Wharton Graduate School of Business
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.