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Nonsteroidal Anti-inflammatory Drug
Ketorolac vs Triamcinolone Injections for Tendinopathy or Arthritis
Phase 4
Recruiting
Led By Amanda L Dempsey
Research Sponsored by Emory University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age 18 or older
Symptomatic tendinopathy or arthropathy of the hand or wrist who have not undergone prior surgical treatment for their condition
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 6 weeks, 24 weeks
Awards & highlights
Study Summary
This trial is testing whether ketorolac or triamcinolone injections are more effective for common hand and wrist tendinopathy or arthropathy, in order to improve pain and function.
Who is the study for?
Adults with painful conditions of the hand or wrist, like trigger finger, De Quervain's tenosynovitis, or osteoarthritis in certain joints. They shouldn't have had surgery for these issues before. People under 18, those who've had similar injections recently, with allergies to the drugs used, or an active infection at the injection site can't join.Check my eligibility
What is being tested?
The trial is testing if Ketorolac or Triamcinolone injections help reduce pain and improve function in patients with tendinopathy or arthropathy of the shoulder, elbow, wrist, and hand. Participants won't know which treatment they get and will be followed up after 6 weeks.See study design
What are the potential side effects?
Possible side effects from Ketorolac might include gastrointestinal problems like ulcers and bleeding; kidney damage; allergic reactions; increased blood pressure. Triamcinolone may cause joint pain increase initially; skin discoloration; weakening of bones.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am 18 years old or older.
Select...
I have hand or wrist joint pain without previous surgery for it.
Select...
I have painful tendon or joint issues in my hand or wrist and haven't had surgery for it.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, 6 weeks, 24 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 6 weeks, 24 weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Changes in Visual Analog Scale (VAS) pain score
Secondary outcome measures
Changes in Grip Strength
Changes in Hand subjectivity value
Changes in Key Pinch
+2 moreTrial Design
2Treatment groups
Active Control
Group I: Ketorolac injection to the shoulder, elbow, wrist, or handActive Control1 Intervention
Participants will receive the Ketoralac injection solutions in a standard fashion. Injections will be performed using the treating physician's standard technique.
Group II: Triamcinolone injection to the shoulder, elbow, wrist, or handActive Control1 Intervention
Participants will receive the triamcinolone injection solutions in a standard fashion. Injections will be performed using the treating physician's standard technique.
Find a Location
Who is running the clinical trial?
American Association for Hand Surgery: AAHSUNKNOWN
Emory UniversityLead Sponsor
1,640 Previous Clinical Trials
2,560,536 Total Patients Enrolled
2 Trials studying Tendinopathy
109 Patients Enrolled for Tendinopathy
American Association for Hand SurgeryUNKNOWN
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am 18 years old or older.I am under 18 years old.I have not had triamcinolone or ketorolac injections in the last 6 months.I have a diagnosis of a hand or wrist condition, such as trigger finger or arthritis in specific joints.I have had surgery for my hand condition before.I am allergic or cannot take triamcinolone or ketorolac injections.I have been diagnosed with a specific hand or wrist joint condition.I do not have an infection at the treatment site.I have hand or wrist joint pain without previous surgery for it.I have painful tendon or joint issues in my hand or wrist and haven't had surgery for it.
Research Study Groups:
This trial has the following groups:- Group 1: Ketorolac injection to the shoulder, elbow, wrist, or hand
- Group 2: Triamcinolone injection to the shoulder, elbow, wrist, or hand
Awards:
This trial has 3 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Drug Has Already Been Approved - The FDA has already approved this drug, and is just seeking more data.
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any open enrollment opportunities for this experiment?
"Unfortunately, this particular trial is no longer enrolling patients. According to clinicaltrials.gov the last update was made on November 29th 2022 and it was originally posted February 1st 2023. Luckily, there are still 777 other trials looking for participants at this moment in time."
Answered by AI
Are any individuals aged fifty or more being recruited for this research endeavor?
"This clinical investigation is open to individuals aged 18 or above, but not exceeding 99 years of age."
Answered by AI
Who would be the ideal participant for this clinical investigation?
"This clinical trial is open to 160 candidates aged 18-99, with a diagnosis of arthrosis. In addition, those wishing to participate must meet the following criteria: have experienced symptomatic tendinopathy or arthropathy in their hand/wrist without prior surgical intervention and identified as having trigger finger, De Quervain's tenosynovitis, radiocarpal osteoarthritis, first carpometacarpal (CMC) joint osteoarthritis, metacarpophalangeal joint osteoarthritis, or proximal interphalangeal joint osteoarthritis."
Answered by AI
Does the FDA permit injections of Ketorolac into the hand or wrist?
"Our team at Power gave Ketorolac injection to the hand or wrist a score of 3 due to its approval status as part of Phase 4 trials."
Answered by AI
Who else is applying?
What state do they live in?
Colorado
Tennessee
Georgia
How old are they?
18 - 65
65+
What site did they apply to?
Emory Saint Joseph's Hospital
12 Executive Park Drive
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
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