A Study of Glutathione in Children With Autism Spectrum Disorder
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing if taking a Glutathione supplement by mouth is safe and practical for children and teenagers with Autism Spectrum Disorder (ASD). The goal is to see if it can help reduce problem behaviors and irritability by increasing Glutathione levels in the blood. Recent evidence shows that children with ASD have significantly lower levels of Glutathione than typically developing children.
Will I have to stop taking my current medications?
The trial requires that you stop taking certain medications, including N-acetylcysteine, milk thistle, Vitamin C, Vitamin B, Grape Seed Extract, Amino Acids, Zinc, Dextromethorphan, D-cycloserine, Amantadine, Memantine, Lamotrigine, or Riluzole before participating.
Is Glutathione generally safe for humans?
Glutathione is a natural compound in the body that helps protect cells from damage. Research suggests it is generally safe, but altering its levels can lead to cellular damage, especially if its synthesis is inhibited. It is important to consult with a healthcare provider before using it as a treatment.12345
How does the drug Glutathione differ from other treatments for this condition?
Glutathione is unique because it acts as a powerful antioxidant, protecting cells from oxidative stress by maintaining proteins in a reduced state and regulating important cellular processes through reversible modifications. This mechanism of action, involving protein S-glutathionylation, is distinct from many other treatments that may not target oxidative stress or redox signaling pathways as directly.16789
What data supports the effectiveness of the treatment Glutathione?
Glutathione plays a crucial role in protecting cells from damage by acting as an antioxidant and detoxifying harmful substances. It is involved in various cellular processes, including immune response and cell survival, which can be beneficial in treating conditions related to oxidative stress and detoxification.35101112
Who Is on the Research Team?
Karam Radwan, MD
Principal Investigator
University of Chicago
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive oral Glutathione supplementation for 12 weeks to evaluate safety and feasibility in children with ASD
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Glutathione
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Chicago
Lead Sponsor