Bupivacaine Injection for Postoperative Pain
Trial Summary
Do I have to stop taking my current medications for this trial?
The trial protocol does not specify whether you need to stop taking your current medications.
What data supports the idea that Bupivacaine Injection for Postoperative Pain is an effective drug?
The available research shows that Bupivacaine Injection, also known as Marcaine or Sensorcaine, is effective in reducing postoperative pain. In one study, patients who received Bupivacaine during breast reduction surgery reported less pain and needed fewer painkillers after the operation. Another study found that using Bupivacaine in surgical wounds helped reduce pain and the need for additional pain medication. Additionally, Bupivacaine was shown to be effective in reducing foot pain after surgery when applied directly to the wound. These studies suggest that Bupivacaine is a reliable option for managing pain after surgery.12345
What safety data is available for Bupivacaine injections?
Bupivacaine, also known as Marcaine or Sensorcaine, has been studied for its safety in various contexts. In obstetrical analgesia, it is noted for minimal side effects on mothers and newborns when used in recommended doses. Intraoperative use in breast reduction surgery and postoperative pain relief in foot surgery has shown it to be effective with no significant side effects. A study on wound perfusion with bupivacaine reported no complications related to toxicity, hypersensitivity, infection, or impaired wound healing. Additionally, pooled safety data from 10 studies on liposome bupivacaine, a novel formulation, have been examined, indicating ongoing evaluation of its safety profile.13456
Is the drug Bupivacaine Injection a promising treatment for postoperative pain?
What is the purpose of this trial?
PlAcebo versus erector spINae pLane block for mEdical ThoracoScopy Study (PAINLESS). This is a prospective triple-blind, randomized controlled trial that evaluates the efficacy of erector spinae plane block (ESPB) with Bupivacaine in reducing pain after medical thoracoscopy (MT) in addition to monitored anesthesia care vs monitored anesthesia care alone.
Research Team
Udit Chaddha, MBBS
Principal Investigator
Principal Investigator
Eligibility Criteria
This trial is for individuals undergoing medical thoracoscopy, a procedure to look inside the chest. Participants should be those who need this procedure and are interested in managing postoperative pain. Specific eligibility details aren't provided, but typically participants must meet certain health criteria.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo medical thoracoscopy with either ESP block with Bupivacaine or placebo
Post-operative Evaluation
Participants are evaluated post-operatively in the post-anesthesia care unit and 24 hours after the procedure
Follow-up
Participants are monitored for pain and recovery quality using various scales
Treatment Details
Interventions
- Bupivacaine
Find a Clinic Near You
Who Is Running the Clinical Trial?
Icahn School of Medicine at Mount Sinai
Lead Sponsor