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Atezolizumab After Chemotherapy for Lung Cancer
Study Summary
This trial is testing a new cancer treatment against the current best treatment, to see if the new treatment is more effective in preventing the cancer from returning.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2019 Phase 3 trial • 1225 Patients • NCT02008227Trial Design
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Who is running the clinical trial?
Media Library
- I haven't taken any immune-boosting drugs in the last 4 weeks or longer.I have had hormone therapy or radiation for cancer within the last 5 years.I have previously been treated with CD137 agonists or immune checkpoint inhibitors.I have active hepatitis B or C.You are allergic to medications made from Chinese hamster ovary cells or any part of the atezolizumab medication.My lung cancer is at an early to mid-stage (Stage IB-IIIA).You have trouble hearing.You have a history of autoimmune disease.You have tested positive for HIV.I am not allergic to any part of the planned chemotherapy or mannitol.I do not have any health conditions that would make it unsafe for me to take a new drug.Your tumor has been tested for a protein called PD-L1 using a specific test in other studies.My cancer is of the squamous cell type.I have taken antibiotics by mouth or IV in the last 14 days.I haven't taken steroids or immunosuppressants in the last 14 days.I have had a bone marrow or organ transplant in the past.I had lung cancer surgery 4-12 weeks ago and have recovered.I haven't had major surgery in the last 28 days and don't expect to need one during the study.I have not had serious heart problems in the last 3 months.I have a history of lung scarring or inflammation not caused by infections.My blood and organs are functioning well.I am fully active or restricted in physically strenuous activity but can do light work.I haven't had any cancer other than NSCLC in the last 5 years, except for very low-risk types.I have active tuberculosis.If you are not past menopause or have had surgery to prevent pregnancy, you need to have a negative pregnancy test within 14 days before starting cisplatin-based chemotherapy.Women who are not past menopause or surgically unable to have children must have a negative pregnancy test within 14 days before starting the treatment.I can understand and follow the study's procedures.I can be treated with cisplatin-based chemotherapy.You have had serious allergic reactions to certain types of medications.I have not received a live vaccine in the last 4 weeks and do not plan to during the study.I have not had chemotherapy in the last 5 years.I have not had signs of infection in the last 14 days.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
- Group 1: Atezolizumab
- Group 2: Best Supportive Care
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
Frequently Asked Questions
Why is Atezolizumab commonly given to patients?
"Atezolizumab is commonly used to treat patients with advance directives. This medication can also be effective at treating other conditions including locally advanced pancreatic adenocarcinoma and malignant neoplasms."
When was Atezolizumab cleared by the FDA?
"Atezolizumab's safety is estimated to be a 3. This evaluation comes from the fact that this drug is in Phase 3 trials, signifying that not only does some data support its efficacy, but multiple rounds of testing have shown it to be safe."
Are people still being enrolled in this experiment?
"This particular clinical study is not presently enrolling patients. The trial was first advertised on October 31st, 2015 and updated most recently on November 7th, 2022. There are 2095 other trials actively recruiting patients with lung cancer and 1657 Atezolizumab trials also admitting patients if you wish to explore other options."
Is Atezolizumab a common ingredient in other medical research?
"Atezolizumab was first researched in 1997 at City of Hope Comprehensive Cancer Center. Out of the 2510 completed studies, 1657 are ongoing with many taking place in Summit, New jersey."
Where are the patients being seen for this trial?
"At the moment, patients are being accepted at Overlook Medical Center; Medical Diagnostic Associates in Summit, New jersey, Va Greater Los Angeles Healthcare System in Sepulveda, California, and VA Puget Sound Health Care Sys in Seattle, Washington. Additionally, there are 61 other potential sites for recruitment."
How many individuals have signed up to participate in this clinical trial?
"This trial is no longer looking for participants. The study was first posted on October 31st, 2015 and the most recent update occurred on November 7th, 2022. If you are interested in other studies, there are currently 2095 active clinical trials related to lung cancer and 1657 with Atezolizumab that need patients."
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