← Back to Search

Monoclonal Antibodies

Tozorakimab for COPD (PROSPERO Trial)

Phase 3
Recruiting
Research Sponsored by AstraZeneca
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 104 weeks.
Awards & highlights

PROSPERO Trial Summary

This trial studies safety & effectiveness of a new COPD treatment. Subjects may be offered a chance to join an extension study.

Who is the study for?
This trial is for adults with symptomatic COPD who've completed the OBERON or TITANIA studies without early discontinuation. They must have taken their last dose within 12 weeks and agree to continue using contraception. Excluded are those with significant health issues, involvement in study planning, inability to follow study requirements, known allergies to trial drugs, or use of certain immunosuppressives.Check my eligibility
What is being tested?
The trial tests Tozorakimab's long-term safety and effectiveness against a placebo in managing COPD symptoms. It's a phase 3 extension from previous studies (OBERON/TITANIA), maintaining a double-blind approach where neither participants nor researchers know who receives the actual drug versus placebo.See study design
What are the potential side effects?
While specific side effects aren't listed here, monoclonal antibodies like Tozorakimab can cause allergic reactions, infusion-related discomforts, immune system changes leading to increased infection risk or inflammation of organs.

PROSPERO Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 104 weeks.
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 104 weeks. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Time to first severe COPD exacerbation in former smokers.
Secondary outcome measures
Annualised rate of moderate to severe COPD exacerbations.
Annualised rate of severe COPD exacerbations.
Incidence of anti-drug antibodies.
+4 more

PROSPERO Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Tozorakimab Dose 2Experimental Treatment1 Intervention
Injection subcutaneously Tozorakimab via pre-filled syringe.
Group II: Tozorakimab Dose 1Experimental Treatment1 Intervention
Injection subcutaneously Tozorakimab via pre-filled syringe.
Group III: PlaceboPlacebo Group1 Intervention
Injection subcutaneously with equivalent volume to Tozorakimab via pre-filled syringe.

Find a Location

Who is running the clinical trial?

AstraZenecaLead Sponsor
4,265 Previous Clinical Trials
288,603,686 Total Patients Enrolled

Media Library

Tozorakimab (Monoclonal Antibodies) Clinical Trial Eligibility Overview. Trial Name: NCT05742802 — Phase 3
Chronic Obstructive Pulmonary Disease Research Study Groups: Tozorakimab Dose 1, Tozorakimab Dose 2, Placebo
Chronic Obstructive Pulmonary Disease Clinical Trial 2023: Tozorakimab Highlights & Side Effects. Trial Name: NCT05742802 — Phase 3
Tozorakimab (Monoclonal Antibodies) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05742802 — Phase 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the age range for this trial limited, and if so what are its upper limits?

"Adhering to the parameters of entry, individuals aged 40 and over but less than 130 can enroll in this medical trial."

Answered by AI

How hazardous is the first dosage of Tozorakimab for patients?

"Our evaluations place Tozorakimab Dose 1's safety at 3, due to the presence of multiple rounds of data confirming efficacy and supporting data for its security."

Answered by AI

In what geographical areas can this clinical trial be accessed?

"This study is currently enrolling patients at 10 sites, including the cities of Newport Beach, Pensacola and Tampa. To reduce travel requirements for potential participants, it may be prudent to choose a medical site close by."

Answered by AI

Are there any remaining openings in this clinical research endeavor?

"As detailed on clinicaltrials.gov, this clinical trial has stopped recruiting participants at present. Initially posted on February 20th 2023 and last updated on the 15th of that same month, there are 472 other research studies actively seeking patients to join their trials right now."

Answered by AI

Are there any criteria restricting participation in this experiment?

"This medical study is enrolling 2544 individuals aged 40 to 130 with chronic obstructive pulmonary disease. To be considered, applicants must have completed the treatment period of predecessor studies within 12 weeks prior and provide a negative urine pregnancy test result. Additionally, female participants need to attest that they are using contraception as agreed in earlier trials before being accepted into this research program. Ultimately, all potential participants must sign an informed consent document to qualify for involvement."

Answered by AI

Who else is applying?

What site did they apply to?
Research Site
Other
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria

Why did patients apply to this trial?

I would like to eliminate the black ball of cancel in my chest.
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
Long-term Efficacy and Safety of Tozorakimab in Participants With Chronic Obstructive Pulmonary Disease With a History of Exacerbations (PROSPERO).
2023. "Long-term Efficacy and Safety of Tozorakimab in Participants With Chronic Obstructive Pulmonary Disease With a History of Exacerbations (PROSPERO).". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05742802.
All > Copd
~798 spots leftby Jul 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top