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ALTO-300 PO tablet for Depression

Phase 2
Waitlist Available
Research Sponsored by Alto Neuroscience
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measured 6 times over 8 weeks
Awards & highlights

Study Summary

This trial will help researchers understand how well ALTO-300 works and what side effects it may cause.

Eligible Conditions
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measured 6 times over 8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and measured 6 times over 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
To evaluate the safety of ALTO-300
To understand the relationship between baseline biology and clinical outcome to ALTO-300 using the Clinical Global Impression scale - Severity (CGI-S)
To understand the relationship between baseline biology and clinical outcome to ALTO-300 using the Montgomery-Åsberg Depression Rating Scale (MADRS)

Trial Design

1Treatment groups
Experimental Treatment
Group I: ALTO-300Experimental Treatment1 Intervention
ALTO-300 tablet PO; daily dosing 8 weeks
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
ALTO-300 PO tablet
2021
Completed Phase 2
~100

Find a Location

Who is running the clinical trial?

Alto NeuroscienceLead Sponsor
7 Previous Clinical Trials
880 Total Patients Enrolled
7 Trials studying Depression
880 Patients Enrolled for Depression

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could I potentially be enrolled in this medical research study?

"To qualify as a participant in this research study, patients should be aged between eighteen and seventy-four years old, experience psychosis and involutional depression. Approximately two hundred individuals will be enrolled for the trial."

Answered by AI

Are any new participants being taken into this research project?

"Affirmative, according to the information on clinicaltrials.gov this investigation is currently seeking volunteers. This inquiry was first published on December 13th 2021 and has been updated most recently on January 3rd 2022 , with a need for 200 patients at one location."

Answered by AI

What is the aggregate count of participants in this research initiative?

"Confirmed. The information available on clinicaltrials.gov reveals that this medical trial is actively seeking participants, which began recruitment on December 13th 2021 and was last updated in the first week of January 2022. Two hundred people are required for this experiment at a single site."

Answered by AI

What potential harms may arise when taking ALTO-300 PO tablet?

"The safety of the ALTO-300 PO tablet has been assessed to be a score 2, since this is an early Phase 2 trial with existing evidence for its security but none regarding efficacy."

Answered by AI

Are the elderly being accepted for recruitment into this investigation?

"To be considered for this trial, applicants must fall between 18 and 74 years of age. There are 192 trials available to those below the legal consenting age while 969 studies target seniors over 65."

Answered by AI

Who else is applying?

What state do they live in?
Texas
How old are they?
18 - 65
What site did they apply to?
Site 102
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
3+

Why did patients apply to this trial?

I have tried many medications, types of therapy, being active, vitamins, etc for treatment and I still suffer and I want to see if something else might work. I also would like to be apart of something that could potentially help others.
PatientReceived no prior treatments
Recent research and studies
clinicaltrials.govStudy
ALTO-300 in Depression
2021. "ALTO-300 in Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05118750.
~27 spots leftby Apr 2025
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