Multiphoton Microscopy for Skin Lesions
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a new method for examining skin lesions (spots or growths on the skin) without cutting the skin. Researchers use a special tool called the MPTflex-multiphoton microscopy-based tomograph to capture detailed images of both pigmented and non-pigmented skin lesions. This tool could help doctors better understand the shape and function of these lesions. Individuals with skin lesions who can follow instructions might be suitable for this trial. As a Phase 1 trial, this research focuses on understanding how the tool functions in people, offering participants a chance to be among the first to benefit from this innovative technology.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that this multiphoton microscopy technique is safe for imaging human skin lesions?
Research has shown that multiphoton microscopy is a safe method for examining human skin. This technique allows scientists to view deep into the skin without incisions. Studies have found that it produces clear images of skin cells and structures. Importantly, similar studies have reported no harmful side effects, suggesting the procedure is well-tolerated. Although this trial is new, past experiences with the technology indicate it is safe for people.12345
Why are researchers excited about this trial?
Researchers are excited about the use of multiphoton microscopy for skin imaging because it offers a non-invasive way to look at skin cells and their structure in real-time. Unlike traditional skin biopsy methods, which require tissue removal and can be uncomfortable, this technique uses laser technology to visualize the skin without any cutting. This method could revolutionize how we assess skin conditions, making the process quicker, painless, and more detailed, which is a big step forward in dermatological diagnostics.
What evidence suggests that this multiphoton microscopy is effective for imaging skin lesions?
Research has shown that multiphoton tomography (MPT), the technology under study in this trial, can capture highly detailed images of the skin, even at the subcellular level. This technology enables virtual skin biopsies, allowing for deep examination without any incisions. Studies have found that MPT reveals important details about skin cells and their functions, aiding in the understanding of various skin conditions. This non-invasive method is gentle and does not involve surgery. So far, MPT has shown promise in providing clear and useful images of both pigmented and non-pigmented skin spots.23678
Who Is on the Research Team?
Kristen Kelly, MD
Principal Investigator
Beckman Laser Institute, UCI
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Imaging
Participants undergo non-invasive skin imaging using multiphoton microscopy to collect information about changes in skin cells and fibrilar structure
Follow-up
Participants are monitored for safety and effectiveness after imaging
What Are the Treatments Tested in This Trial?
Interventions
- MPTflex-multiphoton microscopy-based tomograph
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Multiphoton microscopy imaging to collect information about changes in skin cells and fibrilar structure.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Irvine
Lead Sponsor
Beckman Laser Institute University of California Irvine
Collaborator
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Collaborator
Citations
1.
spiedigitallibrary.org
spiedigitallibrary.org/conference-proceedings-of-spie/13292/1329202/Multimodal-multiphoton-tomography-in-cosmetic-research/10.1117/12.3039966.fullMultimodal multiphoton tomography in cosmetic research
Multiphoton tomography (MPT) provides virtual optical skin biopsies with superior subcellular resolution (300 nm lateral) and metabolic insights.
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The purpose of this pilot study is to employ multiphoton microscopy to non-invasively image in-vivo pigmented and non-pigmented human skin lesions.
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Pilot Study on In-vivo Non-invasive Skin Imaging Using ...
The purpose of this pilot study is to employ multiphoton microscopy to non-invasively image in-vivo pigmented and non-pigmented human skin ...
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