50 Participants Needed

The Use of Lymph Node Biopsies to Support HIV Pathogenesis Studies

MK
RH
Overseen ByRebecca Hoh, RD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of California, San Francisco
Must be taking: Antiretrovirals
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

HIV medicines have led to dramatic improvements in health. However, there remains a concern for potential drug toxicities, cost of drugs, and need for life-long treatment. In addition, research has found that health is not completely restored in HIV-infected patients, even if they have been taking effective HIV medicines for a long time. This may be due to direct drug-toxicity, continued replication of the virus, and/or inflammation of the body in response to the virus. Therefore, a more complete understanding of how HIV stays in the body is necessary.Recent research has shown that one of the places that HIV can stay in the body is in lymphatic tissues such as lymph nodes (even in patients who have been taking HIV medicines for a long time). In addition, the amount of damage to the lymphatic tissues can predict how the immune system (CD4+ T cell count) will respond to therapy.The investigators therefore propose a study in which lymph nodes from the groin area will be removed, with the goals of: 1) seeing how much HIV is in lymph nodes and 2) seeing how much damage has happened to the lymph node architecture.

Who Is on the Research Team?

SD

Steven Deeks, MD

Principal Investigator

University of California, San Francisco

Are You a Good Fit for This Trial?

Inclusion Criteria

Able to give informed consent
No contraindication to surgical procedures
Palpable inguinal adenopathy at study entry
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Lymph Node Biopsy

Lymph nodes from the groin area will be removed to assess HIV presence and lymph node damage

1 day
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after the biopsy procedure

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Lymph node biopsy
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Group I: HIV positiveExperimental Treatment1 Intervention
Group II: HIV negativeExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of California, San Francisco

Lead Sponsor

Trials
2,636
Recruited
19,080,000+

National Institutes of Health (NIH)

Collaborator

Trials
2,896
Recruited
8,053,000+
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