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Cannabinoid

THC for Cognitive Function (THC-MEG Trial)

Q: Does this investigation take into account the participation of individuals who are beyond their thirtieth year?

This trial has a narrow age range requirement, with participants needing to be over 21 and under 65 years old.

Q: Who is the target demographic for this examination?

This medical trial is looking for 50 participants who are between 21 and 65 years old, with thc levels that meet the criteria.

Q: Is there any risk associated with utilizing THC medicinally?

Although efficacy data is not available, there are some reports that suggest THC can be used safely. Thus our team assigned it a score of 2 on the 1 to 3 scale.

Q: Are there any spots available to participate in the trial at this time?

According to information on clinicaltrials.gov, this particular trial is not accepting new participants at the moment. The study was initially posted in December 1st of 2022 and its last edit took place November 29th of that same year. Although this medical investigation isn't looking for candidates currently, there are 9 other studies enrolling patients right now.

Phase 2

Waitlist Available

Led By Jose Cortes-Briones, PhD

Research Sponsored by Yale University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline and starting at +15 minutes after start of iv thc or placebo administration

Awards & highlights

THC-MEG Trial Summary

This trial uses brain scans to measure the effects of THC on brain activity while learning.

Who is the study for?

This trial is for individuals in good physical and mental health who have used cannabis at least once in the past year. They must not use cannabis during the study, confirmed by negative urine tests. People can't join if they've never used cannabis, are pregnant or breastfeeding without birth control, have certain medical or psychiatric conditions, take psychotropic drugs, have a low IQ (<80), weigh over 166kg, or have relatives with major psychotic disorders.Check my eligibility

What is being tested?

The study investigates how THC affects brain activity related to learning using MEG and EEG imaging techniques. Participants will be given either THC or a placebo to compare their brain's response during tasks that involve working memory.See study design

What are the potential side effects?

While the side effects of THC can vary widely among individuals, common ones include altered senses and sense of time, mood changes, impaired body movement coordination, difficulty with thinking and problem-solving as well as potential long-term cognitive effects.

THC-MEG Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline and starting at +15 minutes after start of iv thc or placebo administration

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline and starting at +15 minutes after start of iv thc or placebo administration

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and starting at +15 minutes after start of iv thc or placebo administration for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Changes in brain dynamics during the Sternberg Working Memory Task

Secondary outcome measures

Clinician Administered Dissociative Symptoms Scale (CADSS)

Visual Analog Scale (VAS)

THC-MEG Trial Design

2Treatment groups

Experimental Treatment

Group I: THCExperimental Treatment1 Intervention

Participants will receive THC into a rapidly flowing IV infusion.

Group II: PlaceboExperimental Treatment1 Intervention

Participants will receive an equivalent amount (about 1-2 ml) of placebo (sterile 190 proof USP ethanol). The placebo does not produce any measurable blood alcohol levels or subjective/behavioral effects.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

THC

2017

Completed Phase 1

~330

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor

1,847 Previous Clinical Trials

2,737,618 Total Patients Enrolled

National Institute on Drug Abuse (NIDA)NIH

2,465 Previous Clinical Trials

2,618,583 Total Patients Enrolled

Jose Cortes-Briones, PhDPrincipal InvestigatorYale University

Media Library

THC (Cannabinoid) Clinical Trial Eligibility Overview. Trial Name: NCT05641766 — Phase 2

Tetrahydrocannabinol Research Study Groups: Placebo, THC

Tetrahydrocannabinol Clinical Trial 2023: THC Highlights & Side Effects. Trial Name: NCT05641766 — Phase 2

THC (Cannabinoid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05641766 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this investigation take into account the participation of individuals who are beyond their thirtieth year?

"This trial has a narrow age range requirement, with participants needing to be over 21 and under 65 years old."

Answered by AI

Who is the target demographic for this examination?

"This medical trial is looking for 50 participants who are between 21 and 65 years old, with thc levels that meet the criteria."

Answered by AI

Is there any risk associated with utilizing THC medicinally?

"Although efficacy data is not available, there are some reports that suggest THC can be used safely. Thus our team assigned it a score of 2 on the 1 to 3 scale."

Answered by AI

Are there any spots available to participate in the trial at this time?

"According to information on clinicaltrials.gov, this particular trial is not accepting new participants at the moment. The study was initially posted in December 1st of 2022 and its last edit took place November 29th of that same year. Although this medical investigation isn't looking for candidates currently, there are 9 other studies enrolling patients right now."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks

Jose Cortes 2024. "Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05641766.