Doxycycline for Seromas
What You Need to Know Before You Apply
What is the purpose of this trial?
Seromas are collections of serous fluid that can develop following surgical procedures and may persist as fibrous-lined pseudocysts if not adequately treated. In orthopedic surgery, particularly after arthroplasty, seromas can impair wound healing, increase pain, and limit postoperative rehabilitation, potentially compromising patient recovery. Current treatment strategies including compression, percutaneous aspiration, and repeat surgical intervention have variable success, and aspiration carries the risk of introducing bacteria into an otherwise sterile fluid collection. Sclerotherapy has been proposed as an alternative strategy to induce fibrosis within the cavity and eliminate the potential space. Doxycycline, a tetracycline antibiotic commonly used for pleurodesis, has demonstrated sclerosing properties through mechanisms including mesothelial cell destruction, inhibition of fibrinolysis, and stimulation of fibroblast activity. While doxycycline sclerotherapy has shown success in treating conditions such as Morel-Lavallée lesions and has been described in isolated orthopedic case reports, its role in managing postoperative seromas after arthroplasty remains poorly studied. Further investigation is needed to determine whether doxycycline injection may serve as a safe and effective treatment to reduce persistent seromas and the need for additional interventions in orthopedic patients.
Who Is on the Research Team?
Colin McNamara, MD
Principal Investigator
University of Miami
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single intraoperative dose of doxycycline (500mg) to manage postoperative seromas
Follow-up
Participants are monitored for safety and effectiveness after treatment, including postoperative ultrasounds and patient-reported outcome measures
What Are the Treatments Tested in This Trial?
Interventions
- Doxycycline
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
All participants will receive a single injection intraoperative dose of doxycycline (500mg)
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Miami
Lead Sponsor
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