Nutraceutical for Prostate Cancer

Age: 18+
Sex: Male
Trial Phase: Phase 1 & 2
Sponsor: Optimal Health Research
Must be taking: ADT

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether a supplement called N-111, a nutraceutical, can reduce side effects for men receiving prostate cancer treatment. Participants will receive either N-111 with their usual therapy, a placebo, or just the standard treatment. The goal is to determine if N-111 eases the experience of hormone and radiation therapy. Men currently undergoing both hormone treatment and radiation for prostate cancer might be suitable candidates. As a Phase 1 and Phase 2 trial, this research aims to understand how N-111 works in people and measure its effectiveness in an initial, smaller group, offering participants a chance to contribute to early-stage research.

Do I need to stop taking my current medications for this trial?

The trial information does not specify if you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Is there any evidence suggesting that N-111 is likely to be safe for humans?

A previous study did not provide specific safety data for the nutraceutical N-111. However, as the trial is in the early stages (Phase 1 and Phase 2), N-111 is under careful observation for safety in humans. Early-phase trials typically assess how well participants tolerate a treatment and identify any side effects.

Reaching these phases often indicates that initial tests have not revealed major safety concerns, though this is not guaranteed. Participants should report any side effects they experience to help researchers better understand the treatment's safety.

Prospective participants should discuss any concerns with their doctor, who can provide personalized advice.12345

Why do researchers think this study treatment might be promising?

Unlike the standard of care for prostate cancer, which typically involves androgen deprivation therapy (ADT) and external beam radiation (EBR), N-111 is a nutraceutical that is taken daily with breakfast. Researchers are excited about N-111 because it incorporates natural compounds that might enhance the effectiveness of traditional treatments. This treatment stands out by potentially offering a gentler approach with fewer side effects compared to conventional medications. Additionally, its unique combination with ADT and EBR could improve outcomes by targeting cancer cells through multiple pathways.

What evidence suggests that N-111 might be an effective treatment for prostate cancer?

Research has shown that the supplement N-111, which participants in this trial may receive, might help reduce side effects during prostate cancer treatment. Although direct studies on N-111 are limited, it appears to work in a potentially beneficial way. In this trial, N-111 aims to help the body cope with challenging treatments like hormone therapy (ADT) and radiation (EBR). Early indications suggest it might make these treatments more comfortable, but more information is needed. The goal is to improve comfort during these intense therapies by reducing side effects.678910

Who Is on the Research Team?

AJ

Alan Jeppsen, MD

Principal Investigator

Optimal Health Research

Are You a Good Fit for This Trial?

This trial is for men currently receiving ADT (Androgen Deprivation Therapy) and External Beam Radiation (EBR) for prostate cancer. It's not open to anyone else.

Inclusion Criteria

I am a man being treated for prostate cancer with hormone therapy and external beam radiation.

Exclusion Criteria

Everyone else

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment - EBR

Participants receive External Beam Radiation (EBR) therapy and take N-111 or placebo daily

6 weeks
1 visit per week (in-person)

Treatment - ADT

Participants continue Androgen Deprivation Therapy (ADT) and take N-111 or placebo daily

2 years
1 visit every 3 months (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

6 months

What Are the Treatments Tested in This Trial?

Interventions

  • N-111
Trial Overview The study is testing whether a nutraceutical called N-111 can reduce side effects in patients undergoing ADT + EBR treatment for prostate cancer, compared to a placebo.
How Is the Trial Designed?
3Treatment groups
Active Control
Placebo Group
Group I: N-111Active Control1 Intervention
Group II: ControlActive Control1 Intervention
Group III: PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Optimal Health Research

Lead Sponsor

Trials
9
Recruited
900+

Citations

Comparison of standard-dose and reduced-dose treatment ...Studies were included if primary outcome data were reported for patients with metastatic prostate cancer who had received reduced doses of enzalutamide, ...
Improved Outcomes with Enzalutamide in Biochemically ...In patients with prostate cancer with high-risk biochemical recurrence, enzalutamide plus leuprolide was superior to leuprolide alone with ...
Five-year Survival Prediction and Safety Outcomes with ...Prognostic modeling showed 5-yr survival rates of 42%, 24%, and 5% for low-, intermediate-, and high-risk groups, respectively. Greater degrees of confirmed ...
Apalutamide in Patients With Metastatic Castration- ...The final analysis of TITAN confirmed that, despite crossover, apalutamide plus ADT improved OS, delayed castration resistance, maintained ...
a head-to-head analysis of real-world patients in the USAThe results of this study show that compared with abiraterone acetate, initial treatment with apalutamide resulted in better real-world survival ...
Radioimmunotherapy with 111 In/ 90 Y-2IT-BAD-m170 for ...For additional safety, the injected radioactivity (GBq) was not allowed to be more than that which would cause a greater radiation dose (Gy) to normal organs ...
Treatment Intensification in Metastatic Prostate CancerThe findings of this study suggest that physician education on treatment guidelines, efficacy and safety data, and appropriate prostate-specific antigen goals ...
Prostate Cancer - StatPearls - NCBI Bookshelf - NIHSeveral commercial genomic tests can now reliably estimate a patient's prognosis, tumor aggressiveness, and relative genetic risk from a single prostate cancer ...
The Safety Analysis of the Prostate Cancer Study-5, a ...The safety of moderate HF RT in patients with low, intermediate, or mixed-risk prostate cancer has been confirmed in multiple phase 3 trials.19, 20, 21, 22, 23, ...
Emerging evidence for sequencing and combining PSMA- ...PSMA is highly expressed in the prostate cancer adenocarcinoma ... Safety data and efficacy data were presented at the Beyond PSMA ...
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