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Methoxyamine + Chemotherapy for Mesothelioma
Study Summary
This trial is testing the side effects and best dose of methoxyamine when given with cisplatin and pemetrexed disodium to see if it can treat patients with solid tumors or mesothelioma that have spread and usually cannot be cured or controlled with standard treatment, or mesothelioma that does not respond to pemetrexed disodium and cisplatin or carboplatin.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Frequently Asked Questions
How many patients are involved in this clinical research project?
"This study is no longer recruiting participants. The trial was initially posted on August 11th, 2015 and updated for the final time on November 15th, 2022. There are 4951 trials currently enrolling patients with recurrent peritoneal malignant mesothelioma and 865 studies involving Methoxyamine that are actively looking for participants."
Can people with the required medical conditions participate in this trial at this time?
"Unfortunately, this study is not recruiting patients at the moment. The listing was published on August 11th, 2015 and last edited November 15th, 2022. However, there are 4951 other trials for recurrent peritoneal malignant mesothelioma and 865 for Methoxyamine that are still enrolling patients if you're interested."
How has Methoxyamine been traditionally employed?
"Methoxyamine has shown to be an effective treatment against malignant neoplasms, ovarian cancer, and unresectable thymoma."
Is this clinical trial also being conducted in any other locations besides Canada?
"Currently, this clinical trial has 15 sites open for enrollment. These locations are situated in Columbus, Nashville and Madison with other cities making up the remaining 12 locations. If you are selected to participate, it would be most convenient for you if the site was close to your location to reduce travel requirements."
What goals does this research hope to achieve?
"The purpose of this 8-week study is to establish a maximum tolerated dose (in Arm A). Additionally, the trial will monitor for objective clinical responses (defined as RECIST-defined responses summarized as a fraction of all subjects), and feasibility of establishing pleural and peritoneal effluent-derived cell lines. Lastly, cultured mesothelioma cells' response to cisplatin, pemetrexed, and methoxyamine in patients will be compared."
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