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Radiation

Pre-op RT +/- chemotherapy for Mesothelioma

Phase 1 & 2
Waitlist Available
Led By John Cho, MD
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Suitable for combined modality therapy
Informed consent
Timeline
Screening 3 weeks
Treatment Varies
Follow Up after completion of therapy: every 4 wks for 3 mos, then every 6 wks for 6 mos, then every 2 mos for 12 mos, then every 3 mos for 2 yrs, then every 6 mos for 5 years
Awards & highlights

Study Summary

This trial is testing whether a short course of radiation therapy to the chest given before surgery will help to prevent the spread of a type of cancer associated with asbestos exposure.

Who is the study for?
This trial is for adults with a new diagnosis of Malignant Pleural Mesothelioma (MPM) who are in good health otherwise, have not had previous chemotherapy or thoracic radiation, and are not pregnant. They should be able to undergo surgery and have an ECOG performance status of 0-2.Check my eligibility
What is being tested?
The study tests if short intense chest radiation before surgery can prevent the spread of tumor cells during the operation. It's followed by extrapleural pneumonectomy (EPP), which may include additional chemotherapy after surgery.See study design
What are the potential side effects?
Potential side effects might include typical reactions to radiation therapy such as skin changes, fatigue, nausea, and lung inflammation. Surgery-related risks also apply.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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You are able to receive multiple types of treatments for your condition.
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You have given permission and fully understand what the study involves.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~after completion of therapy: every 4 wks for 3 mos, then every 6 wks for 6 mos, then every 2 mos for 12 mos, then every 3 mos for 2 yrs, then every 6 mos for 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and after completion of therapy: every 4 wks for 3 mos, then every 6 wks for 6 mos, then every 2 mos for 12 mos, then every 3 mos for 2 yrs, then every 6 mos for 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Therapeutic procedure
Secondary outcome measures
To evaluate: acute and late morbidity related to treatment; local & distant recurrence, disease free & overall survival; identify factors/parameters associated with increased risk of treatment morbidity

Trial Design

1Treatment groups
Experimental Treatment
Group I: AllExperimental Treatment1 Intervention
This is a single arm study. All patients enrolled will be in this arm.

Find a Location

Who is running the clinical trial?

University Health Network, TorontoLead Sponsor
1,456 Previous Clinical Trials
482,699 Total Patients Enrolled
5 Trials studying Mesothelioma
1,509 Patients Enrolled for Mesothelioma
John Cho, MDPrincipal InvestigatorUniversity Health Network, Toronto
5 Previous Clinical Trials
345 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the recruitment period for this experiment still open?

"Unfortunately, according to clinicaltrials.gov records this trial is not currently open for recruitment. It made its original appearance on October 1st 2008 and was last modified on the 6th of October 2022. Nevertheless, 152 other trials remain active and they are actively seeking participants at present."

Answered by AI
~3 spots leftby Sep 2024