Sodium Bicarbonate for Kidney Stones
What You Need to Know Before You Apply
What is the purpose of this trial?
Kidney stones affect 1 in every 11 people in the US each year. In patients with kidney stones who are prescribed medications for stone management, only 30.2% are adherent to a medication regime and even fewer, only 13.4 % are adherent with citrate medications.
Prescription potassium citrate can be expensive for many patients, leading to non-compliance. Sodium bicarbonate is a potential medication alternative that is cheaper and can potentially alkalinize the urine and/or decrease the risk of future kidney stones. However, efficacy of alternatives to potassium potassium citrate are not well studied.
This study seeks to evaluate sodium bicarbonate and assess its ability to alkalinize urine in a cohort of patients with kidney stones and compare this to prescription potassium citrate.
Who Is on the Research Team?
Kymora B Scotland, MD, PhD
Principal Investigator
University of California, Los Angeles
Are You a Good Fit for This Trial?
This trial is for adults over 18 with a history of kidney stones, specifically those who have low citrate levels in their urine and are currently using or considering potassium citrate for stone prevention.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 1 week of sodium bicarbonate followed by 1 week of potassium citrate after a washout period, or vice versa.
Follow-up
Participants are monitored for changes in urine pH, urinary ammonia excretion, and urinary citrate excretion.
What Are the Treatments Tested in This Trial?
Interventions
- Sodium Bicarbonate
Trial Overview
The study compares the effectiveness of sodium bicarbonate to prescription potassium citrate in alkalinizing urine among patients with kidney stones. It aims to determine if sodium bicarbonate can be a cheaper alternative.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Receives 1 week of sodium bicarbonate, then 1 week of potassium citrate after washout.
1 week of potassium citrate first, then sodium bicarbonate after a washout.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Los Angeles
Lead Sponsor
University of California, Davis
Collaborator
Brigham and Women's Hospital
Collaborator
Landspitali University Hospital
Collaborator
University of California, San Diego
Collaborator
Centre hospitalier de l'Université de Montréal (CHUM)
Collaborator
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.