Focused Ultrasound Neuromodulation for Affective Disorders
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing a new treatment using sound waves to target a part of the brain in people with emotional disorders like depression and anxiety. The treatment aims to change how this part of the brain works to improve symptoms. It is non-invasive and uses MRI to monitor changes in the brain.
Will I have to stop taking my current medications?
The trial requires that your psychiatric medications be on a stable dosage and regimen for the past 3 months, so you should not stop taking them if they meet this criterion.
How is focused ultrasound treatment different from other treatments for affective disorders?
Focused ultrasound treatment is unique because it is non-invasive and can precisely target deep brain areas involved in mood regulation, unlike other methods like transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS). This allows for high spatial resolution and the ability to modulate specific brain circuits without surgery.12345
Who Is on the Research Team?
Gregory A Fonzo, Ph.D.
Principal Investigator
The University of Texas at Austin
Are You a Good Fit for This Trial?
This trial is for adults aged 18-65 with a primary diagnosis of major depression, bipolar disorder, anxiety disorder, or PTSD. Participants must be proficient in English, able to undergo MRI and focused ultrasound treatments up to 15 times over 2-6 weeks, and have been on stable psychiatric medication for the past three months.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive low-intensity focused ultrasound targeting the left amygdala, once a day, 5 days a week, for 3 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Focused ultrasound
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Texas at Austin
Lead Sponsor