ProChondrix CR for Cartilage Damage
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a treatment called ProChondrix CR, a cartilage repair product, to determine its effectiveness for knee pain caused by cartilage damage. The focus is on improving physical function and reducing knee pain, specifically targeting defects on the femoral condyle or patella. Individuals with moderate to severe knee pain, unresponsive to other treatments, might be suitable candidates. Participants should have a stable knee and be prepared for a procedure that combines marrow stimulation with ProChondrix CR. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, offering participants a chance to benefit from a potentially effective new therapy.
Do I need to stop my current medications to join the trial?
The trial information does not specify if you need to stop taking your current medications. However, if you have received hyaluronic acid injections into the joint space within 90 days before surgery, you may not be eligible.
Is there any evidence suggesting that ProChondrix CR is likely to be safe for humans?
Research has shown that ProChondrix CR, a type of cartilage graft, is generally safe. It maintains a high number of living, healthy cells. Studies report that 94.97% of the cells in ProChondrix CR remain alive after two years of storage, indicating the treatment's stability over time.
Thorough testing of the donor tissue used for ProChondrix CR ensures safety and helps reduce the risk of negative reactions. Overall, evidence suggests that ProChondrix CR is well-tolerated, making it a promising option for treating cartilage problems.12345Why do researchers think this study treatment might be promising?
ProChondrix CR is unique because it uses a fresh osteochondral allograft, which is a graft taken from donor cartilage tissue, to repair articular cartilage defects. Unlike traditional treatments like microfracture surgery or autologous chondrocyte implantation, which rely on stimulating the patient's own cartilage to heal, ProChondrix CR directly provides live, healthy cartilage cells and essential growth factors to the damaged area. Researchers are excited about this approach because it has the potential to improve cartilage repair by more closely mimicking the natural structure and function of healthy cartilage, potentially leading to better and faster recovery outcomes.
What evidence suggests that ProChondrix CR might be an effective treatment for symptomatic cartilage defects?
Studies have shown that ProChondrix CR can lead to positive outcomes for people with knee cartilage damage. Research indicates that this treatment can improve movement and reduce knee pain. In the short term, patients reported better results after using ProChondrix CR for issues in specific knee areas, such as the kneecap and the end of the thigh bone. A review of studies found that treatments like ProChondrix CR have a high success rate, with 86.7% still effective after five years. These findings suggest that ProChondrix CR may be an effective option for repairing knee cartilage damage.26789
Who Is on the Research Team?
Jill Bagdasarian
Principal Investigator
AlloSource
Beth Esterl
Principal Investigator
AlloSource
Elizabeth Esterl, DNP, MS, RN
Principal Investigator
AlloSource
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo surgical intervention for cartilage defect repair using ProChondrix CR
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- ProChondrix CR
Find a Clinic Near You
Who Is Running the Clinical Trial?
AlloSource
Lead Sponsor