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LY3305677 for Obesity

Phase 1
Waitlist Available
Research Sponsored by Eli Lilly and Company
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up predose up to 72 hours postdose
Awards & highlights

Study Summary

This trial will investigate the safety & tolerability of LY3305677 when given to participants with obesity/overweight. Blood tests will monitor how the drug affects the body. Each participant will receive injections & the study will last 28 weeks.

Eligible Conditions
  • Obesity

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~predose up to 72 hours postdose
This trial's timeline: 3 weeks for screening, Varies for treatment, and predose up to 72 hours postdose for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Participants with One or More Treatment Emergent Adverse Events (TEAEs) and Serious Adverse Event(s) (SAEs) Considered by the Investigator to be Related to Study Drug Administration
Secondary outcome measures
PK: Area Under the Concentration Versus Time Curve (AUC) of LY3305677
Pharmacodynamics (PD): Percentage change in Body Weight
Pharmacokinetics (PK): Maximum Concentration (Cmax) of LY3305677

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: LY3305677Experimental Treatment1 Intervention
LY3305677 administered subcutaneously (SC)
Group II: PlaceboPlacebo Group1 Intervention
Placebo administered SC
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
LY3305677
2017
Completed Phase 1
~180

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Eli Lilly and CompanyLead Sponsor
2,613 Previous Clinical Trials
3,200,897 Total Patients Enrolled
53 Trials studying Obesity
40,796 Patients Enrolled for Obesity
Study DirectorEli Lilly and Company
1,344 Previous Clinical Trials
405,220 Total Patients Enrolled
36 Trials studying Obesity
20,515 Patients Enrolled for Obesity

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What level of hazard is associated with LY3305677?

"Our team at Power gave LY3305677 a score of 1 as it is currently in its first phase, rendering the available data on safety and efficacy rather sparse."

Answered by AI

Is the window of opportunity for participants still available?

"Affirmative. Clinicaltrials.gov's repository confirms that this clinical trial is currently enrolling participants, as it was first shared on November 16th 2022 and altered most recently on the 28th of the same month. The study requires 32 individuals to be recruited between 2 different sites."

Answered by AI

Is the enrollment of individuals aged 50 and over being solicited for this clinical trial?

"This trial is accessible to individuals aged 18-70."

Answered by AI

Which demographics are eligible to partake in this experiment?

"This experiment is welcoming 32 volunteers suffering from obesity, aged between 18 and 70. These applicants must pass a medical check-up; plus have been maintaining the same weight for 3 months with BMI scores ranging from 27 to 50 kg/m²."

Answered by AI

What is the maximum enrollment number for this medical trial?

"Indeed, the clinical trial is open for enrollment. Based on information from clinicaltrials.gov, it was initiated November 16th 2022 and last updated November 28th 2022; 32 individuals are required to participate at two sites."

Answered by AI

Who else is applying?

What state do they live in?
Louisiana
New York
Texas
What site did they apply to?
ICON Early Phase Services
What portion of applicants met pre-screening criteria?
Did not meet criteria
How many prior treatments have patients received?
0
1

Why did patients apply to this trial?

I cannot seem to lose this weight for the life of me and it’s ruining my health. I need severe help.
PatientReceived no prior treatments
I've tried to reduce my weight due to health problems but can't seem to do it myself. Would like help but don't want to pay. I have never been able to exercise regularly.
PatientReceived 2+ prior treatments

What questions have other patients asked about this trial?

When’s the soonest that I can start?
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
A Study of LY3305677 in Participants With Obesity Or Overweight
2022. "A Study of LY3305677 in Participants With Obesity Or Overweight". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05623839.
~13 spots leftby Apr 2025
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