Povorcitinib + Ruxolitinib for Healthy Subjects
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to evaluate the interstitial concentrations using the open-flow microperfusion device and plasma pharmacokinetics following multiple doses of povorcitinib or topical ruxolitinib cream in healthy adult participants.
Who Is on the Research Team?
Incyte Medical Monitor
Principal Investigator
Incyte Corporation
Are You a Good Fit for This Trial?
This trial is for healthy adults aged 18 to 65 with a BMI between 18.0 and 30.5, no significant health issues, able to swallow pills, willing to avoid pregnancy during the study, and able to give informed consent.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive multiple doses of oral povorcitinib or topical ruxolitinib cream
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Povorcitinib
- Ruxolitinib Cream
Trial Overview
The study compares how the body absorbs and processes multiple doses of an oral drug (povorcitinib) versus a topical cream (ruxolitinib) in healthy volunteers using special monitoring devices.
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Povorcitinib will be administered at the protocol defined dose.
Povorcitinib will be administered at the protocol defined dose.
Ruxolitinib cream applied topically twice daily.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Incyte Corporation
Lead Sponsor
Steven Stein
Incyte Corporation
Chief Medical Officer since 2015
MD from University of Witwatersrand
Hervé Hoppenot
Incyte Corporation
Chief Executive Officer since 2014
MBA from ESSEC Business School
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