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Ibuprofen 800 mg for Bone Fractures

Phase 1
Waitlist Available
Research Sponsored by United States Army Research Institute of Environmental Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from pre-exercise to 4 hours post-exercise
Awards & highlights

Study Summary

This trial will test the effects of NSAIDs on post-workout bone and muscle health.

Eligible Conditions
  • Bone Fractures
  • Osteoporosis
  • Stress Fractures

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from pre-exercise to 4 hours post-exercise
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from pre-exercise to 4 hours post-exercise for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change from baseline circulating marker of bone formation
Secondary outcome measures
Change from baseline circulating marker of bone resorption
Markers of muscle inflammation
Other outcome measures
Muscle protein synthesis

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: IbuprofenExperimental Treatment1 Intervention
Participants will consume a single dose of ibuprofen prior to a plyometric exercise bout
Group II: FlurbiprofenExperimental Treatment1 Intervention
Participants will consume a single dose of flurbiprofen prior to a plyometric exercise bout
Group III: CelecoxibExperimental Treatment1 Intervention
Participants will consume a single dose of celecoxib prior to a plyometric exercise bout
Group IV: PlaceboPlacebo Group1 Intervention
Participants will consume a single dose of an inert placebo prior to a plyometric exercise bout
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ibuprofen 800 mg
2007
Completed Phase 4
~1040
Celecoxib 200mg
2022
Completed Phase 4
~710
Flurbiprofen 100 mg
2022
Completed Phase 1
~40

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

United States Army Research Institute of Environmental MedicineLead Sponsor
59 Previous Clinical Trials
3,418 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it reasonable to assume any risks with the ingestion of Ibuprofen 800 mg?

"Based on the available data, we assign Ibuprofen 800mg a score of 1, as this is an early stage trial and there is only limited evidence supporting its safety and efficacy."

Answered by AI

Is it within the parameters of this trial to include participants aged 85 or younger?

"As per the inclusion criteria, only individuals aged 18 to 42 are eligible for this specific clinical trial. Conversely, there is a separate study conducted for those under 18 and another one dedicated to participants above 65 years old."

Answered by AI

Are there vacancies for individuals to participate in this research trial?

"Affirmative. Clinicaltrials.gov's records suggest that this experiment is presently enrolling participants; it was initially published on February 15th 2022 and underwent its latest edit on August 19th 2022. A total of 12 subjects must be enlisted from a single research centre to complete the study."

Answered by AI

Is it possible to join the current clinical research?

"This medical research requires 12 participants of ages 18 to 42, who had bone resorption. To qualify for the study, they must also agree to cease alcohol and nicotine consumption during each trial period (4 trials over 5 days), have a minimum level of physical activity at least twice per week, abstain from taking non-steroidal anti-inflammatory drugs unless given by the investigators and weigh no less than 110 lbs with hemoglobin levels higher than 12.5 g/dL or above."

Answered by AI

To what extent has enrollment been achieved in this medical experiment?

"Affirmative. Clinicaltrials.gov reports that this experiment, which was inaugurated on February 15th 2022, is currently recruiting subjects. The trial necessitates 12 participants from one medical facility."

Answered by AI
Recent research and studies
~4 spots leftby Apr 2025