Metformin for Preventing Type 2 Diabetes After Gestational Diabetes
Trial Summary
Will I have to stop taking my current medications?
The trial protocol does not specify whether you need to stop taking your current medications. However, if you are using systemic steroids, you would not be eligible to participate.
What data supports the effectiveness of the drug Metformin for preventing type 2 diabetes after gestational diabetes?
Is metformin generally safe for humans?
How does the drug metformin differ from other treatments for preventing type 2 diabetes after gestational diabetes?
Metformin is unique because it has been shown to effectively reduce the risk of developing type 2 diabetes in women with a history of gestational diabetes, and it is well tolerated. Unlike some other treatments, metformin has a long history of safe use for blood sugar control, and it can be used alone or alongside lifestyle changes, making it a flexible option for prevention.1112131415
What is the purpose of this trial?
The overall goal of this proposal is to create and test an implementation protocol for in-hospital immediate postpartum diabetes screening for postpartum patients with pregnancies affected by GDM.
Research Team
Gianna Wilkie, MD
Principal Investigator
UMASS Memorial Healthcare
Eligibility Criteria
This trial is for postpartum patients who had gestational diabetes (GDM) and show signs of high blood sugar. They must have been diagnosed with GDM in their third trimester, be able to give consent, speak English or Spanish, and be capable of undergoing glucose testing immediately after delivery at UMASS Memorial.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Early Postpartum GDM Screening
Subjects are screened for GDM with a 2-hour glucose tolerance test during their postpartum hospitalization
Standard of Care Postpartum Screening
Subjects receive the usual standard of care with a 2-hour glucose tolerance test at 6-12 weeks postpartum
Follow-up
Participants are monitored for glycemic outcomes and patient satisfaction after screening
Treatment Details
Interventions
- Metformin Hydrochloride
Metformin Hydrochloride is already approved in European Union, United States, Canada, Japan for the following indications:
- Type 2 diabetes
- Polycystic ovary syndrome
- Type 2 diabetes
- Polycystic ovary syndrome
- Gestational diabetes
- Type 2 diabetes
- Polycystic ovary syndrome
- Type 2 diabetes
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Massachusetts, Worcester
Lead Sponsor