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VR-Reward Training for Depression (VR-RT Trial)

Phase 1
Recruiting
Led By Michelle G Craske, Ph.D
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
At least 18 years old
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline to follow-up (week 12)
Awards & highlights

VR-RT Trial Summary

This trial is testing whether VR-Reward Training can help people with depression and low positive affect by teaching them to savor positive experiences. 80 people will be randomly assigned to either VR-Reward Training or VR-Memory Training, and will complete in-person VR sessions, laboratory assessments, and self-report questionnaires over the course of 3 months.

Who is the study for?
This trial is for adults who feel very little pleasure or interest in activities (anhedonia), may be experiencing depression, and have trouble functioning daily. They must speak English fluently, not be on psychotropic drugs, and agree not to start other psychological treatments during the study. People with bipolar disorder, psychosis, substance use issues in the last six months, or those prone to motion sickness can't join.Check my eligibility
What is being tested?
The study tests if Virtual Reality-Reward Training (VR-RT), which uses VR to help people enjoy positive experiences more deeply, is better than a control activity called Virtual Reality-Memory Training (VR-MT) at improving mood and reducing symptoms of depression over seven weeks.See study design
What are the potential side effects?
Potential side effects are not detailed but could include discomfort from using VR such as dizziness or nausea especially for those prone to motion sickness. There's also a risk of emotional distress given the focus on mental health.

VR-RT Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18 years old or older.

VR-RT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline to follow-up (week 12)
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to follow-up (week 12) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Depression, Anxiety, and Stress Scales (DASS-21)
MASQ-AD 14 Item
The Positive Affect and Negative Affect Schedule-Expanded Form (PANAS X) (General Dimensions Scales)
Secondary outcome measures
Behavioral Activation Scale (BAS)
Effort Reward Trade-off Task
Positive Valence Systems Scale (PVSS-21)
+3 more

VR-RT Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Virtual Reality-Reward Training (VR-RT)Experimental Treatment1 Intervention
7 sessions of positive VR immersion and positive memory specificity training exercises designed to savor rewarding features of immersion followed by memory specificity training exercises to savor rewarding features of autobiographical memory.
Group II: Virtual Reality-Memory Training (VR-MT)Active Control1 Intervention
7 sessions of neutral VR immersion and neutral memory specificity training exercises, designed to train memory of objective non-emotional stimuli followed by memory exercises to neutral autobiographical memories.

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Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,530 Previous Clinical Trials
10,264,628 Total Patients Enrolled
101 Trials studying Depression
48,363 Patients Enrolled for Depression
Michelle G Craske, Ph.DPrincipal InvestigatorUniversity of California, Los Angeles

Media Library

Virtual Reality-Reward Training (VR-RT) Clinical Trial Eligibility Overview. Trial Name: NCT05342077 — Phase 1
Depression Research Study Groups: Virtual Reality-Memory Training (VR-MT), Virtual Reality-Reward Training (VR-RT)
Depression Clinical Trial 2023: Virtual Reality-Reward Training (VR-RT) Highlights & Side Effects. Trial Name: NCT05342077 — Phase 1
Virtual Reality-Reward Training (VR-RT) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05342077 — Phase 1
Depression Patient Testimony for trial: Trial Name: NCT05342077 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the main objective of this clinical experiment?

"This clinical trial plans to monitor the effects of the medication over a 12-week period by measuring participants' Depression, Anxiety, and Stress Scales (DASS-21). Secondary outcomes being tracked include changes in reported anhedonia through MASQ-AD 14 Item scores, anticipatory pleasure with Temporal Experience of Pleasure Scale (TEPS), as well as Positive and Negative Affective Schedule (PANAS) results for positive affect and negative affect."

Answered by AI

Is this experiment in search of new participants?

"Indeed, the relevant information on clinicaltrials.gov attests to this research program's ongoing recruitment drive. Initially posted on September 15th 2022 and last edited around that same time period, 80 individuals need to be selected from a single study site."

Answered by AI

Has the FDA formally sanctioned Virtual Reality-Reward Training (VR-RT)?

"The safety of Virtual Reality-Reward Training (VR-RT) has been assessed as a 1 due to its Phase 1 status, indicating that the data supporting efficacy and security is limited."

Answered by AI

How many participants are actively engaged in this experiment?

"Confirmed. Data hosted on clinicaltrials.gov shows that this particular medical trial was first published on September 15th 2022 and is still actively recruiting participants. A total of 80 people are expected to be enrolled at one site."

Answered by AI

Who else is applying?

What state do they live in?
Texas
California
How old are they?
18 - 65
What site did they apply to?
University of California, Los Angeles
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
0
3+

Why did patients apply to this trial?

Please email me if with more details. I have had several diagnosis of being Moderately Depressed and given Cimbalta, Seroquel and lately 2023-Bupropion 150mg.
PatientReceived no prior treatments
I have tried SSRI's, therapy, I checked myself into an inpatient facility, I really really want to have this saddnes and confusion out of my life.
PatientReceived no prior treatments

What questions have other patients asked about this trial?

Recent research and studies
clinicaltrials.govStudy
Virtual Reality-Reward Training for Anhedonia
Michelle Craske 2022. "Virtual Reality-Reward Training for Anhedonia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05342077.
All > Depression Los Angeles
~24 spots leftby Dec 2024
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