Accelerated TMS for Chronic Pain
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new method for managing chronic pain using accelerated intermittent theta burst stimulation (aiTBS), a form of transcranial magnetic stimulation (TMS). The researchers aim to determine if targeting specific brain areas can safely and effectively reduce pain. Advanced technology identifies the optimal treatment spot based on each person's unique patterns. Individuals with chronic pain lasting at least a year, who have not found relief with standard medications, may be suitable candidates for this study. As a Phase 1 trial, the research focuses on understanding how the treatment works in people, offering participants the opportunity to be among the first to receive this innovative approach.
What prior data suggests that this method is safe for treating chronic pain?
Previous studies have shown that aiTBS is safe and well-tolerated for chronic pain. Research indicates that patients found this treatment practical and acceptable. Importantly, all patients in one study passed a safety check, and their medication routines remained unchanged before the study, suggesting few side effects or disruptions. Overall, these findings support the idea that aiTBS is a safe option for managing chronic pain.12345
Why do researchers think this study treatment might be promising for chronic pain?
Accelerated Intermittent Theta Burst Stimulation (aiTBS) is unique because it offers a non-invasive approach to managing chronic pain. Unlike traditional treatments like medications and physical therapy, aiTBS uses targeted magnetic pulses to stimulate specific brain areas, which may lead to quicker and more efficient pain relief. Researchers are excited about aiTBS because it has the potential to provide rapid benefits, possibly reducing the need for long-term medication use and its associated side effects.
What evidence suggests that accelerated intermittent theta burst stimulation (aiTBS) is effective for chronic pain?
Research has shown that accelerated intermittent theta burst stimulation (aiTBS), which participants in this trial will receive, may help reduce chronic pain. Studies have found that people receiving aiTBS experienced more pain relief compared to those who received a placebo treatment, with significant results. Specifically, one study showed that 80% of patients in the aiTBS group experienced more pain relief than those in the placebo group. Additionally, aiTBS has proven safe and effective for other conditions, suggesting it could be a helpful tool for managing pain. This therapy targets brain areas involved in pain, aiming to change how pain signals are processed. While more research is needed, the initial findings are promising.23456
Who Is on the Research Team?
Alexander B Herman, MD, PhD
Principal Investigator
University of Minnesota
David Darrow
Principal Investigator
University of Minnesota
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive accelerated intermittent theta burst stimulation (aiTBS) targeting personalized nodes within the somato-cognitive action network (SCAN) and action motor network (AMN) for chronic pain treatment
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Accelerated Intermittent Theta Burst Stimulation (aiTBS)
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Individuals with chronic pain
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Minnesota
Lead Sponsor
The Foundation for the Advancement of Clinical TMS
Collaborator
Citations
Accelerated intermittent theta burst transcranial magnetic ...
This study assessed feasibility, safety, and tolerability of accelerated intermittent theta burst stimulation (aiTBS) with effective connectivity-guidance ...
Accelerated Intermittent Theta Burst Stimulation (AiTBS)on ...
The present study was designed to be the first to evaluate the efficacy of the AiTBS protocol to relieve neuropathic pain in a therapeutic setting, ...
Efficacy and safety of intermittent theta-burst stimulation ... - PMC
The therapeutic efficacy and safety profiles of daily or accelerated intermittent theta-burst stimulation (iTBS) in comparison to daily or ...
Accelerated Theta Burst in Chronic Pain: A Biomarker Study
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for chronic pain.
Accelerated Intermittent Theta Burst Stimulation
study demonstrates safety and significant efficacy of Stanford neuromodulation therapy (SNT) in a placebo-controlled design with 29 participants ...
Accelerated Theta Burst Stimulation (aTBS): Safety, efficacy ...
We discuss the stimulation parameters that seem to be important for the efficacy of accelerated TBS protocols and possible avenues for further optimization.
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