Transcranial Temporal Interference Stimulation for Healthy Adults
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a new brain stimulation method called Transcranial Temporal Interference Stimulation (TIS), which targets specific brain areas without surgery. Researchers aim to understand how this technology affects the brain's motor cortex, the area controlling movement. They will test different TIS frequencies to determine the most effective approach for future medical treatments. Participants must be right-handed adults without neurological or orthopedic conditions that could affect participation.
As an unphased trial, this study allows participants to contribute to groundbreaking research that could lead to innovative treatments for neurological conditions.
Will I have to stop taking my current medications?
Yes, you will need to stop taking most prescription and over-the-counter medications to participate in this trial, except for birth control and certain allergy medications.
What prior data suggests that transcranial temporal interference stimulation is safe for humans?
Earlier studies used a technique called transcranial temporal interference stimulation (TIS) on 820 people over several sessions. The findings show that TIS is generally safe and well-tolerated. Some participants experienced minor effects like changes in attention or mood, but serious side effects were rare. Researchers have ensured that the stimulation levels remain safe for humans. Although TIS is still under investigation, the results so far suggest it is a promising and safe option for brain stimulation.12345
Why are researchers excited about this trial?
Researchers are excited about Transcranial Temporal Interference Stimulation (TTIS) because it offers a novel way to modulate brain activity using non-invasive electrical stimulation. Unlike traditional treatments that might rely on medication or direct electrical stimulation at a single frequency, TTIS uses two high-frequency currents that intersect to create a low-frequency electrical field deep in the brain. This approach allows for targeted stimulation without needing surgical implants or surface electrodes, potentially offering a safer and more precise option for influencing brain function. By exploring different frequency combinations, researchers hope to better understand how specific brain regions can be selectively activated, which might open up new avenues for treating various neurological conditions.
What evidence suggests that transcranial temporal interference stimulation is effective for neuromodulation?
Studies have shown that transcranial temporal interference stimulation (TIS) can reach deep brain areas without surgery. Human trials found TIS safe and easy to tolerate. Some early research suggests it may help with short-term improvements in conditions like Parkinson's and epilepsy. Additionally, TIS has been linked to better memory and faster reaction times in healthy individuals. Although more research is needed, these findings highlight TIS's potential to effectively change brain activity. Participants in this trial will join different experimental arms testing various frequencies of TIS, or a sham comparator, to further explore its effects on brain activity.12367
Who Is on the Research Team?
Mathew Yarossi, PhD
Principal Investigator
Northeastern University
Are You a Good Fit for This Trial?
This trial is for healthy adults. People with any neurological or psychiatric conditions, implanted medical devices, or other health issues that could interfere with brain stimulation are likely excluded.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Application of transcranial temporal interference stimulation (TIS) to the motor cortex and assessment of corticospinal excitability using transcranial magnetic stimulation (TMS)
Follow-up
Participants are monitored for neuroplastic effects and retention of neuromodulation post-stimulation
What Are the Treatments Tested in This Trial?
Interventions
- Transcranial Temporal Interference Stimulation
Trial Overview
Researchers are testing a new non-invasive brain stimulation method called transcranial temporal interference stimulation (TIS) on the motor cortex to see how it affects brain activity and excitability in healthy people.
How Is the Trial Designed?
6
Treatment groups
Experimental Treatment
Placebo Group
990-1010 Hz fb
2000-2000 Hz fb
20 Hz
1990-2010 Hz fb
1000-1000 Hz fb
sham
Find a Clinic Near You
Who Is Running the Clinical Trial?
Northeastern University
Lead Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator
Citations
Human Applications of Transcranial Temporal Interference ...
Phase 1 studies demonstrate that tTIS is safe, well-tolerated, and capable of engaging deep brain targets in humans. Well-controlled Phase 2 trials are needed ...
Overcoming the Barriers to Effective Transcranial Temporal ...
Transcranial temporal interference stimulation (TIS) is a non-invasive neuromodulation method with much more favorable focus in deep brain ...
Systematic review of experimental studies in humans on ...
Clinical evidence remains limited, with two Parkinson's pilots and one epilepsy study showing short-term benefits. Overall, tTIS shows potential ...
Human Applications of Transcranial Temporal Interference ...
Conclusions Phase 1 studies demonstrate that tTIS is safe, well-tolerated, and capable of engaging deep brain targets in humans. Well-controlled ...
5.
ctv.veeva.com
ctv.veeva.com/study/overcoming-the-barriers-to-effective-transcranial-temporal-interference-stimulation-in-humansOvercoming the Barriers to Effective Transcranial Temporal ...
Safety and tolerability of TIS has recently been demonstrated in humans with findings indicating that TIS poses no greater risk than other ...
Temporal Interference | Brainbox
Transcranial temporal interference stimulation (tTIS, TI) aims to non-invasively stimulate deep brain regions by manipulating certain electrical properties ...
7.
centerwatch.com
centerwatch.com/clinical-trials/listings/NCT07339072/temporal-interference-methods-for-non-invasive-deep-brain-stimulation-study-12Temporal Interference Methods for Non-invasive Deep ...
The investigators will investigate whether TI stimulation can increase BOLD activity in targeted deep brain regions including the nucleus ...
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.