Melatonin for High Blood Pressure
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines how melatonin may help manage high blood pressure in women undergoing menopause. Researchers aim to determine if taking melatonin for 12 weeks improves blood pressure compared to a placebo (a pill with no active ingredient). The trial targets women aged 40-55 who have begun experiencing menopause symptoms, such as irregular periods, and have been diagnosed with high blood pressure. Participants must not currently use sleep medications or melatonin. As an unphased trial, this study provides an opportunity to contribute to understanding how melatonin might benefit women with high blood pressure during menopause.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you must be on a stable medical regimen for at least 2 months if you are taking other medications.
Is there any evidence suggesting that melatonin is likely to be safe for humans?
Research has shown that melatonin is generally safe to use. For example, studies have found that taking melatonin regularly can lower blood pressure during sleep without affecting heart rate, indicating it is well-tolerated for short-term use.
However, some studies suggest that melatonin might raise blood pressure in individuals already on blood pressure medication, so discussing this with a doctor is important. Another study found that melatonin does not negatively affect arterial flexibility, supporting its safety.
In summary, melatonin appears safe for most people, especially for short-term use, but those on blood pressure medication should exercise caution.12345Why are researchers excited about this trial?
Unlike the standard treatments for high blood pressure, which often include medications like ACE inhibitors, beta-blockers, and diuretics, melatonin is a naturally occurring hormone that regulates sleep. Researchers are excited about melatonin because it has the potential to lower blood pressure by improving sleep quality and reducing nighttime blood pressure levels. This treatment could offer a gentler approach with fewer side effects compared to traditional medications. Plus, since melatonin is a widely used supplement for sleep disorders, it may be more accessible and affordable for patients.
What evidence suggests that melatonin might be an effective treatment for high blood pressure?
Research has shown that melatonin can help lower blood pressure. In some studies, taking melatonin at night reduced the systolic blood pressure (when the heart beats) by 6 mm Hg and the diastolic pressure (when the heart rests) by 4 mm Hg during sleep, without affecting heart rate. Another study found that melatonin also helped lower diastolic blood pressure during the day in adults. Additionally, melatonin has lowered blood pressure in both humans and animals. In this trial, participants will receive either melatonin or a placebo to observe its effects on cardiovascular risk measures in perimenopausal women. These findings suggest that melatonin could be a useful treatment for high blood pressure, especially at night.24678
Who Is on the Research Team?
Naima Covassin, Ph.D.
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for women aged 40-55 who are in the menopause transition, with high blood pressure. They must have an intact uterus and at least one ovary, fit the STRAW bleeding pattern criteria for perimenopause, and be on a stable medication regimen if taking other drugs.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive melatonin or placebo supplementation for 12 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Melatonin
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor