Electrical Stimulation for Cerebral Palsy
(CP Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if gentle electrical stimulation can help children with cerebral palsy (CP) walk more easily. The technique, known as neuromuscular electrical stimulation (NMES), sends small pulses to the muscles to aid activation. Researchers will test various NMES methods to identify the most effective approach. Children with CP who can walk with or without assistance and experience crouch, equinus, or jump gait may be suitable candidates for this study. As an unphased trial, this study provides a unique opportunity to explore innovative treatments that could enhance mobility in children with CP.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, it does mention that participants should be seizure-free or have well-controlled seizures, which might imply that continuing seizure medication is allowed.
What prior data suggests that this method is safe for children with cerebral palsy?
Research shows that neuromuscular electrical stimulation (NMES) is generally safe for children with cerebral palsy. Studies have found that it can improve movement and muscle strength without causing serious side effects. For example, one study found that NMES helped children stand, run, and jump better. Another study showed it increased muscle size and strength.
Regarding safety, NMES sessions proved safe and practical. Most sessions did not encounter major problems, although the long-term effects remain not fully understood. Overall, children seem to tolerate NMES well.12345Why are researchers excited about this trial?
Researchers are excited about Neuromuscular Electrical Stimulation (NMES) for cerebral palsy because it offers a new approach by using low-power electrical impulses to stimulate specific muscles during movement. Unlike traditional therapies that often rely on physical exercises and medications to manage symptoms, NMES directly engages and strengthens the muscles involved in walking, potentially improving mobility in a more targeted way. This technique could enhance muscle coordination and strength more effectively, providing a promising alternative to standard care options.
What evidence suggests that NMES is effective for cerebral palsy?
Research has shown that neuromuscular electrical stimulation (NMES) can enhance movement in children with cerebral palsy. In this trial, participants in the Cerebral Palsy Group will receive NMES on various combinations of their lower limb muscles while walking on a treadmill. Studies have found that NMES can improve their ability to stand, run, and jump. It sends small electrical signals to the muscles, strengthening and enlarging them. Some research also suggests that NMES can increase muscle strength and reduce muscle tightness in these children. Overall, NMES has consistently improved physical abilities for this group.12678
Who Is on the Research Team?
Ahad Behboodi, PhD
Principal Investigator
University of Nebraska
Are You a Good Fit for This Trial?
This trial is for children with cerebral palsy who can walk on a treadmill. Specific eligibility criteria are not provided, but typically participants must be in stable health and able to comply with study requirements.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Assessment
Participants undergo two assessment sessions with NMES applied to leg muscles while walking on a treadmill
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- NMES
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Nebraska
Lead Sponsor
National Institute of General Medical Sciences (NIGMS)
Collaborator