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Nerve Block + Dexamethasone for Migraine

Q: Are there vacancies available to participants for this research?

Results posted on the clinicaltrials.gov website suggest that this medical trial is no longer searching for candidates. The original posting was made on August 28th 2023 and modified most recently on August 24th 2023. This said, there remain 1,245 other trials currently seeking participants.

Q: Does this trial extend to geriatric patients?

This medical trial seeks participants aged 18 to 85. On the other hand, there are 194 studies available for minors and 1052 clinical trials that cater to seniors.

Q: Could I be considered a qualified participant for this experiment?

To qualify for this <a href="https://www.withpower.com/clinical-trials/migraine">migraine</a> research, individuals must be aged 18 to 85. A total of 84 participants are required in order to successfully complete the trial.

Phase < 1

Recruiting

Research Sponsored by Texas Tech University Health Sciences Center, El Paso

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Nerve block performed with bupivacaine 0.5%

Had a minimum 5-point reduction in headache intensity after nerve block(s) or post- block pain score of 0 to 2

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 72-96hrs post treatment

Awards & highlights

Study Summary

This trial found PHNB + steroids can help reduce migraine recurrence over the next few days for some ER patients.

Who is the study for?

This trial is for individuals who meet the criteria for migraine headaches and have experienced significant relief after a nerve block treatment. They must not have head trauma, suspicion of secondary headache causes like stroke or tumors, be chronically on steroids, have allergies to dexamethasone, uncontrolled diabetes, or compromised immune systems.Check my eligibility

What is being tested?

The study tests if adding oral dexamethasone to a peripheral headache nerve block can prevent the recurrence of migraines within 72 hours post-treatment. Participants will either receive dexamethasone or a placebo alongside their usual migraine management.See study design

What are the potential side effects?

Dexamethasone may cause side effects such as sleep problems (insomnia), mood changes, increased appetite leading to weight gain, indigestion, and potential increase in blood sugar levels.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have had a nerve block with a specific medication.

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My headache pain decreased significantly after a nerve block.

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I have been diagnosed with migraines according to ICHD-3 standards.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 72-96hrs post treatment

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~72-96hrs post treatment

This trial's timeline: 3 weeks for screening, Varies for treatment, and 72-96hrs post treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Recurrence of headache

Secondary outcome measures

Early recurrence headache and timing

side effects of dexamethasone identified if any

Side effects data

From 2013 Phase 4 trial • 122 Patients • NCT01474915

Deep Vein Thrombosis

Cerebrospinal fluid leak

Fever

100%

80%

60%

40%

20%

Study treatment Arm

Ondansetron

Aprepitant

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: DexamethasoneExperimental Treatment1 Intervention

single oral dose of dexamethasone (8mg)

Group II: PlaceboPlacebo Group1 Intervention

Single oral dose of placebo pill

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Dexamethasone Oral

2020

N/A

~14110

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Texas Tech University Health Sciences Center, El PasoLead Sponsor

49 Previous Clinical Trials

5,036 Total Patients Enrolled

Susan Watts, PhD.Study DirectorTexas Tech University Health Sciences Center, Department of Emergency Medicine

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there vacancies available to participants for this research?

"Results posted on the clinicaltrials.gov website suggest that this medical trial is no longer searching for candidates. The original posting was made on August 28th 2023 and modified most recently on August 24th 2023. This said, there remain 1,245 other trials currently seeking participants."

Answered by AI

Does this trial extend to geriatric patients?

"This medical trial seeks participants aged 18 to 85. On the other hand, there are 194 studies available for minors and 1052 clinical trials that cater to seniors."

Answered by AI

Could I be considered a qualified participant for this experiment?

"To qualify for this migraine research, individuals must be aged 18 to 85. A total of 84 participants are required in order to successfully complete the trial."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?

Edward Michelson, MD 2023. "Does Nerve Block + Oral Dexamethasone Reduce Recurrence of Headache Within 72 Hrs?". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06016465.

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