Treatment for Glioblastoma

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Stony Brook University Hospital, Stony Brook, NYGlioblastomaAtezolizumab + FSRT radiation - CombinationProduct
Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary

This trialstudies a new combo treatment for Glioblastoma, a malignant brain tumor. Patients will receive a 2 week combination of radiotherapy and a drug, then have surgery and continue with the drug.

Eligible Conditions
  • Glioblastoma

Treatment Effectiveness

Effectiveness Progress

1 of 3

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Infigratinib
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Niraparib
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Atezolizumab

Study Objectives

2 Primary · 0 Secondary · Reporting Duration: 2 years

2 years
Number of participants who progress/relapse after surgical resection
Day 30
Number of participants with treatment-related adverse events as assessed by CTCAE v5.0

Trial Safety

Safety Progress

1 of 3

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1
Infigratinib
1
Niraparib
1
Atezolizumab

Side Effects for

Atezolizumab
27%Fatigue
25%Decreased appetite
24%Cough
19%Dyspnoea
19%Asthenia
18%Constipation
18%Nausea
18%Pyrexia
16%Diarrhoea
13%Arthralgia
12%Anaemia
12%Vomiting
11%Rash
11%Musculoskeletal pain
11%Back pain
10%Headache
9%Insomnia
9%Oedema peripheral
9%Weight decreased
9%Chest pain
9%Pruritus
9%Pain in extremity
8%Dizziness
7%Myalgia
7%Aspartate aminotransferase increased
7%Haemoptysis
7%Upper respiratory tract infection
6%Influenza like illness
6%Alanine aminotransferase increased
6%Nasopharyngitis
6%Bronchitis
6%Productive cough
5%Dry skin
5%Depression
5%Musculoskeletal chest pain
4%Abdominal pain
4%Urinary tract infection
4%Neuropathy peripheral
4%Paraesthesia
3%Pneumonia
3%Stomatitis
3%Dysgeusia
2%Neutropenia
2%Pleural effusion
2%Malaise
1%Peripheral sensory neuropathy
1%Pulmonary embolism
1%Respiratory tract infection
1%Lacrimation increased
1%Sepsis
1%Pneumonitis
1%Alopecia
1%Mucosal inflammation
1%Bone pain
This histogram enumerates side effects from a completed 2019 Phase 3 trial (NCT02008227) in the Atezolizumab ARM group. Side effects include: Fatigue with 27%, Decreased appetite with 25%, Cough with 24%, Dyspnoea with 19%, Asthenia with 19%.

Trial Design

1 Treatment Group

Treatment
1 of 1

Experimental Treatment

12 Total Participants · 1 Treatment Group

Primary Treatment: Treatment · No Placebo Group · Phase < 1

Treatment
CombinationProduct
Experimental Group · 1 Intervention: Atezolizumab + FSRT radiation · Intervention Types: CombinationProduct

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 2 years

Who is running the clinical trial?

Stony Brook UniversityLead Sponsor
201 Previous Clinical Trials
35,582 Total Patients Enrolled
1 Trials studying Glioblastoma
13 Patients Enrolled for Glioblastoma
Genentech, Inc.Industry Sponsor
1,503 Previous Clinical Trials
565,426 Total Patients Enrolled
34 Trials studying Glioblastoma
1,954 Patients Enrolled for Glioblastoma
Alexander Stessin, MDPrincipal InvestigatorStony Brook Cancer Center

Eligibility Criteria

Age 18+ · All Participants · 7 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
References

Frequently Asked Questions

Is enrolment for this experiment still accessible?

"Clinicaltrials.gov indicates that this research study is presently searching for participants, with initial posting on September 21st 2022 and the most recent edit occurring November 2nd 2022." - Anonymous Online Contributor

Unverified Answer

How extensive is the current participation in this clinical experiment?

"Affirmative. Clinicaltrials.gov corroborates that this trial is actively seeking participants, having been first listed on September 21st 2022 and modified most recently on November 2nd 2022. This study requires a total of 12 patients from 1 medical centre." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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