Dr. Zachariah DeFilipp, MD
Claim this profileMassachusetts General Hospital
Area of expertise
Acute Graft-versus-Host Disease
Zachariah DeFilipp, MD has run 3 trials for Acute Graft-versus-Host Disease. Some of their research focus areas include:
Acute Myeloid Leukemia
Zachariah DeFilipp, MD has run 2 trials for Acute Myeloid Leukemia. Some of their research focus areas include:
Affiliated Hospitals
Massachusetts General Hospital
Harvard Medical School - Massachusetts General Hospital - Cancer Center
Clinical Trials Zachariah DeFilipp, MD is currently running
Extended vs Short-Term Abatacept Dosing
for Graft-versus-Host Disease
This is a multicenter randomized, double blind, Phase 2 trial for patients receiving transplants from 7 of 8 HLA matched donors, in which an extended dosing regimen of abatacept, and a short-term dosing regimen + placebo, when added to standard calcineurin inhibitor + methotrexate-based prophylaxis, will be compared for their ability to improve outcomes in patients with a minimum follow-up of one year post-transplant. All patients will receive 4 doses of abatacept (Days -1, +5, +14, +28). Prior to the fifth dose, patients will be randomly assigned to the 4-dose abatacept arm and receive 4 doses of placebo or 8-dose abatacept arm and receive 4 more doses of abatacept. The primary endpoint of the study will be severe AGVHD-free, severe CGVHD-free, relapse-free survival (SGRFS). The study will end when the last patient has reached 2 years after transplant. Results will first be calculated and the study unblinded when the last patient has reached one year post-transplant.
Recruiting
0 awards
Phase 2
Ziftomenib
for Acute Myeloid Leukemia
The purpose of this study is to test the safety, effects, and recommended dose of an investigational drug, ziftomenib, in addition to the standard treatment on blood cancer with Allogeneic Hematopoietic Cell Transplantation (allo-HCT). This study plans to learn more about ziftomenib, which targets and inhibits negative interactions within cancer cells related to AML, when given after allo-HCT, to determine if it improves outcomes following allo-HCT. The name of the study drug involved in this study is: • Ziftomenib
Recruiting
1 award
Phase 1
7 criteria
More about Zachariah DeFilipp, MD
Clinical Trial Related
4 years of experience running clinical trials · Led 9 trials as a Principal Investigator · 3 Active Clinical Trials
Treatments Zachariah DeFilipp, MD has experience with
- Placebo
- Ziftomenib
- Autologous Hematopoietic Cell Transplantation
- Standard Preventive And Supportive Care Therapies
- AB-205
- SER-155
Breakdown of trials Zachariah DeFilipp, MD has run
Acute Graft-versus-Host Disease
Acute Myeloid Leukemia
Mixed-Cell Lymphoma
Central Nervous System Hodgkin Lymphoma
Non-Hodgkin's Lymphoma
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Zachariah DeFilipp, MD specialize in?
Zachariah DeFilipp, MD focuses on Acute Graft-versus-Host Disease and Acute Myeloid Leukemia. In particular, much of their work with Acute Graft-versus-Host Disease has involved Stage I patients, or patients who are Stage II.
Is Zachariah DeFilipp, MD currently recruiting for clinical trials?
Yes, Zachariah DeFilipp, MD is currently recruiting for 3 clinical trials in Boston Massachusetts. If you're interested in participating, you should apply.
Are there any treatments that Zachariah DeFilipp, MD has studied deeply?
Yes, Zachariah DeFilipp, MD has studied treatments such as Placebo, Ziftomenib, Autologous Hematopoietic Cell Transplantation.
What is the best way to schedule an appointment with Zachariah DeFilipp, MD?
Apply for one of the trials that Zachariah DeFilipp, MD is conducting.
What is the office address of Zachariah DeFilipp, MD?
The office of Zachariah DeFilipp, MD is located at: Massachusetts General Hospital, Boston, Massachusetts 02114 United States. This is the address for their practice at the Massachusetts General Hospital.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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