Dr. Wade Kyono, MD - Pediatric ...

Dr. Wade T. Kyono

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Kapiolani Medical Center for Women and Children

Expert in Cancer
Expert in Brain Tumor
55 reported clinical trials
105 drugs studied

About Wade T. Kyono

Education:

  • Obtained MD from the John A. Burns School of Medicine, University of Hawaiʻi at Mānoa in 2009.
  • Completed Residency in Pediatrics at Kapiʻolani Medical Center for Women & Children (2009-2012).
  • Undertook Fellowship in Pediatric Critical Care Medicine at Kapiʻolani Medical Center for Women & Children (2012-2015).

Experience:

  • Currently serves as a Pediatric Critical Care Physician at Kapiolani Medical Center for Women and Children.

Area of expertise

1Cancer
Global Leader
Wade T. Kyono has run 17 trials for Cancer. Some of their research focus areas include:
Stage I
Stage IV
Stage II
2Brain Tumor
Global Leader
Wade T. Kyono has run 12 trials for Brain Tumor. Some of their research focus areas include:
Stage I
Stage II
Stage IV

Affiliated Hospitals

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Kapiolani Medical Center For Women And Children
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Straub Clinic And Hospital

Clinical Trials Wade T. Kyono is currently running

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Selumetinib vs. Chemotherapy

for Brain Cancer

This trial is comparing a new drug, selumetinib, with standard chemotherapy to treat patients with a specific type of brain tumor. The patients do not have a certain genetic mutation and are not affected by a genetic disorder. Selumetinib works by blocking enzymes needed for tumor growth, while the standard drugs kill or stop tumor cells from dividing.
Recruiting2 awards Phase 3
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Inotuzumab Ozogamicin

for Acute Lymphoblastic Leukemia

This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymphoblastic lymphoma (B-LLy) when treated with ALL therapy without inotuzumab ozogamicin. Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a type of chemotherapy called calicheamicin. Inotuzumab attaches to cancer cells in a targeted way and delivers calicheamicin to kill them. Other drugs used in the chemotherapy regimen, such as cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine, vincristine, and pegaspargase or calaspargase pegol work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial will also study the outcomes of patients with mixed phenotype acute leukemia (MPAL) and disseminated B lymphoblastic lymphoma (B-LLy) when treated with high-risk ALL chemotherapy. The overall goal of this study is to understand if adding inotuzumab ozogamicin to standard of care chemotherapy maintains or improves outcomes in High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL). The first part of the study includes the first two phases of therapy: Induction and Consolidation. This part will collect information on the leukemia, as well as the effects of the initial treatment, to classify patients into post-consolidation treatment groups. On the second part of this study, patients with HR B-ALL will receive the remainder of the chemotherapy cycles (interim maintenance I, delayed intensification, interim maintenance II, maintenance), with some patients randomized to receive inotuzumab. The patients that receive inotuzumab will not receive part of delayed intensification. Other aims of this study include investigating whether treating both males and females with the same duration of chemotherapy maintains outcomes for males who have previously been treated for an additional year compared to girls, as well as to evaluate the best ways to help patients adhere to oral chemotherapy regimens. Finally, this study will be the first to track the outcomes of subjects with disseminated B-cell Lymphoblastic Leukemia (B-LLy) or Mixed Phenotype Acute Leukemia (MPAL) when treated with B-ALL chemotherapy.
Recruiting2 awards Phase 3

More about Wade T. Kyono

Clinical Trial Related8 years of experience running clinical trials · Led 55 trials as a Principal Investigator · 19 Active Clinical Trials
Treatments Wade T. Kyono has experience with
  • Cyclophosphamide
  • Radiation Therapy
  • Etoposide
  • Doxorubicin Hydrochloride
  • Vincristine Sulfate
  • Laboratory Biomarker Analysis

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