Dr. Steven Kirshblum, MD | West Orange ...

Dr. Steven Kirshblum, MD

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Kessler Institute for Rehabilitation

Studies Spinal Cord Injury
Studies Osteoporosis
10 reported clinical trials
11 drugs studied

Affiliated Hospitals

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Kessler Institute For Rehabilitation
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Kessler Foundation

Clinical Trials Steven Kirshblum, MD is currently running

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Romosozumab + Denosumab

for Spinal Cord Injury

The objective of the proposed work is to determine whether administration for 12 months of romosozumab (evenity) followed by 12 months of denosumab (prolia) will maintain bone mass at the knee in subjects with chronic SCI.
Recruiting3 awards Phase 45 criteria
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Shockwave Therapy

for Spinal Cord Injury

People with spinal cord injury (SCI) experience a host of secondary complications that can impact their quality of life and functional independence. One of the more prevalent complications is spasticity, which occurs in response to spinal cord damage and the resulting disruption of motor pathways. Common symptoms include spasms and stiffness, and can occur more than once per hour in many people with SCI. Spasticity can have a negative impact over many quality of life domains, including loss of functional independence, activity limitations, and even employment. Its impact on health domains is also pronounced, with many people who have spasticity reporting mood disorders, depression, pain, sleep disturbances, and contractures. Spasticity can interfere with post-injury rehabilitation and lead to hospitalization. There are many treatments for spasticity in this population. However, many do not have long-term efficacy, and, if they do, they are often pharmacological in nature and carry side effects that could limit function or affect health. The goal of this pilot, randomized-controlled study is to investigate the potential efficacy and safety of a non-invasive treatment with a low side effect profile, extracorporeal shockwave therapy (ESWT). ESWT has shown some benefits in people with post-stroke spasticity with no long term side effects. Thirty individuals with chronic, traumatic SCI will be recruited. Fifteen will be provided with ESWT while the other fifteen will be given a sham treatment. Clinical and self-report measures of spasticity and its impact on quality of life will be collected, as well as quantitative ultrasound measures of muscle architecture and stiffness. The ultimate goal of this pilot project is to collect the data necessary to apply for a larger randomized-controlled trial. Conducting a larger trial will allow for a more powerful estimation of safety and efficacy of ESWT as a treatment for spasticity in people with SCI.
Recruiting0 awards N/A6 criteria

More about Steven Kirshblum, MD

Clinical Trial Related4 years of experience running clinical trials · Led 10 trials as a Principal Investigator · 4 Active Clinical Trials
Treatments Steven Kirshblum, MD has experience with
  • Denosumab
  • Romosozumab
  • Romoszumab
  • BQ 2.0
  • Whole Body Vibration
  • Mirabegron

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