Dr. Stephanie A. Toll
Claim this profileChildren's Hospital of Michigan
Studies Brain Tumor
Studies Brain Cancer
8 reported clinical trials
21 drugs studied
Area of expertise
1Brain Tumor
Stage I
Stage II
Stage IV
2Brain Cancer
Stage I
Stage II
Stage IV
Affiliated Hospitals
Clinical Trials Stephanie A. Toll is currently running
Selumetinib vs. Chemotherapy
for Brain Cancer
This trial is comparing a new drug, selumetinib, with standard chemotherapy to treat patients with a specific type of brain tumor. The patients do not have a certain genetic mutation and are not affected by a genetic disorder. Selumetinib works by blocking enzymes needed for tumor growth, while the standard drugs kill or stop tumor cells from dividing.
Recruiting2 awards Phase 3
Chemotherapy + Radiation Therapy
for Brain Cancer
This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) optimizing radiation for patients who respond well to induction chemotherapy to diminish spinal cord relapses, 2) utilizing higher dose chemotherapy followed by conventional RT in patients who did not respond to induction chemotherapy. Chemotherapy drugs, such as carboplatin, etoposide, ifosfamide, and thiotepa, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays or high-energy protons to kill tumor cells and shrink tumors. Studies have shown that patients with newly-diagnosed localized NGGCT, whose disease responds well to chemotherapy before receiving radiation therapy, are more likely to be free of the disease for a longer time than are patients for whom the chemotherapy does not efficiently eliminate or reduce the size of the tumor. The purpose of this study is to see how well the tumors respond to induction chemotherapy to decide what treatment to give next. Some patients will be given RT to the spine and a portion of the brain. Others will be given high dose chemotherapy and a stem cell transplant before RT to the whole brain and spine. Giving treatment based on the response to induction chemotherapy may lower the side effects of radiation in some patients and adjust the therapy to a more efficient one for other patients with localized NGGCT.
Recruiting1 award Phase 2
More about Stephanie A. Toll
Clinical Trial Related5 years of experience running clinical trials · Led 8 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Stephanie A. Toll has experience with
- Tipifarnib
- Selpercatinib
- Selumetinib Sulfate
- Selumetinib
- Carboplatin; Vincristine Sulfate
- Memantine Hydrochloride
Breakdown of trials Stephanie A. Toll has run
Brain Tumor
Brain Cancer
Low Grade Glioma
Mixed-Cell Lymphoma
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Stephanie A. Toll specialize in?
Stephanie A. Toll focuses on Brain Tumor and Brain Cancer. In particular, much of their work with Brain Tumor has involved Stage I patients, or patients who are Stage II.
Is Stephanie A. Toll currently recruiting for clinical trials?
Yes, Stephanie A. Toll is currently recruiting for 2 clinical trials in Detroit Michigan. If you're interested in participating, you should apply.
Are there any treatments that Stephanie A. Toll has studied deeply?
Yes, Stephanie A. Toll has studied treatments such as Tipifarnib, Selpercatinib, Selumetinib Sulfate.
What is the best way to schedule an appointment with Stephanie A. Toll?
Apply for one of the trials that Stephanie A. Toll is conducting.
What is the office address of Stephanie A. Toll?
The office of Stephanie A. Toll is located at: Children's Hospital of Michigan, Detroit, Michigan 48201 United States. This is the address for their practice at the Children's Hospital of Michigan.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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