UofT Radiation Oncology Residents on X ...

Dr. Srinivas Raman

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University Health Network

Studies Prostate Cancer
Studies Cancer
6 reported clinical trials
21 drugs studied

Affiliated Hospitals

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University Health Network
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Princess Margaret Cancer Centre

Clinical Trials Srinivas Raman is currently running

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Early vs Delayed Salvage Radiotherapy

for Prostate Cancer

The investigators will randomize patients presenting with early BCR with a negative baseline PSMA PET/CT, to upfront SRT or surveillance. Early BCR is defined as a PSA relapse of \>0.1 to \<0.3 ng/mL. Patients in the surveillance arm will be monitored with PSA every 3 months. A repeat PSMA PET/CT will be undertaken when the PSA reaches a target level of \>0.5 to \<1.0 ng/mL. Both early radiation treatment and surveillance with repeat PSMA PET/CT imaging are within patterns of practice locally; therefore, the investigators believe that there is clinical equipoise on this subject.
Recruiting1 award Phase 2
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SBRT

for Oligo-Progressive Cancer

Systemic therapy is the main treatment for patients with metastatic cancers. Oligo-progression has become a recognized entity for metastatic cancer and it is thought that a subset of cancer cells may develop heterogeneity and resistant clones while receiving systemic therapy. This results in overall tumor response but progression in metastatic sites. Current standard is to change systemic therapies. With advancing technologies, stereotactic body radiation therapy is being used to deliver high doses of focused radiation to the disease site, while minimizing risk of injury to the surrounding organs. SBRT is increasingly being used in patients presenting oligo-metastatic disease, and is recognized as having a potential for cure. This study will investigate the use of SBRT for breast and genito-urinary cancer patients with oligo-progression. Patients will be seen before and at the end of treatment and will be followed at 4 month intervals for up to 2 years. During the visits participants will complete quality of life questionnaires and will have standard of care imaging. Patients will also have the option to provide blood at baseline, during treatment, and at various follow up time points for analysis of ctDNA
Recruiting1 award N/A19 criteria

More about Srinivas Raman

Clinical Trial Related5 years of experience running clinical trials · Led 6 trials as a Principal Investigator · 3 Active Clinical Trials
Treatments Srinivas Raman has experience with
  • High Dose Rate Brachytherapy
  • Low Dose Rate Brachytherapy
  • Stereotactic Body Radiotherapy
  • Darolutamide
  • External Beam Radiotherapy
  • Luteinizing Hormone-Releasing Hormone Analog

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