Dr. Siddharth Singh, MD
Claim this profileUC San Diego Health
Studies Ulcerative Colitis
Studies Crohn's Disease
2 reported clinical trials
3 drugs studied
Affiliated Hospitals
Clinical Trials Siddharth Singh, MD is currently running
Weight Loss Drug
for Ulcerative Colitis
Approximately 20-40% of patients with ulcerative colitis (UC) are obese. The investigators have demonstrated that obesity adversely impacts disease course in patients with UC, leading to higher risk of persistently active disease, surgery, hospitalization, and treatment failure, particularly in biologic-treated patients. Intentional weight loss is effective in improving disease outcomes in patients with inflammatory arthritis, but there is limited data on its impact in UC. While dietary interventions for weight loss have limited efficacy and endoscopic bariatric interventions may be too invasive in patients with UC with active gastrointestinal symptoms, pharmacological weight loss with a highly effective oral agent may be a novel strategy to induce weight loss and augment the efficacy of biologic therapy in UC. Hence, the investigators are conducting a pilot, phase 2A, 22-week, randomized, placebo-controlled clinical trial of phentermine-topiramate in obese patients with active UC starting on a new biologic agent (infliximab, adalimumab, golimumab, vedolizumab). The overall objective is to (1) evaluate the efficacy, safety and tolerability of phentermine-topiramate, and (2) to assess the impact of pharmacological weight loss on clinical outcomes, inflammatory burden and biologic trough concentration in patients with UC. The central hypothesis is that phentermine-topiramate will be safe, effective, and well tolerated in patients with UC, and weight loss would achieve higher rates of clinical and biochemical remission, and higher biologic trough concentration.
Recruiting0 awards Phase 27 criteria
Immunomodulator Strategy
for Inflammatory Bowel Disease
The purpose of this study is to compare the effectiveness and safety of a strategy of switching to an alternative targeted immunomodulator (TIM) therapy to treat to a target of endoscopic remission, versus continuing index TIM in patients with inflammatory bowel disease (IBD) (Crohn's disease or ulcerative colitis \[UC\]) in symptomatic remission with moderate to severe endoscopic inflammation despite optimization of index TIM in a real-world setting.
Recruiting1 award N/A
More about Siddharth Singh, MD
Clinical Trial Related4 years of experience running clinical trials · Led 2 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Siddharth Singh, MD has experience with
- Pragmatic
- Phentermine-Topiramate
- Placebo
Breakdown of trials Siddharth Singh, MD has run
Ulcerative Colitis
Crohn's Disease
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Siddharth Singh, MD specialize in?
Siddharth Singh, MD focuses on Ulcerative Colitis and Crohn's Disease. In particular, much of their work with Ulcerative Colitis has involved treating patients, or patients who are undergoing treatment.
Is Siddharth Singh, MD currently recruiting for clinical trials?
Yes, Siddharth Singh, MD is currently recruiting for 2 clinical trials in La Jolla California. If you're interested in participating, you should apply.
Are there any treatments that Siddharth Singh, MD has studied deeply?
Yes, Siddharth Singh, MD has studied treatments such as Pragmatic, Phentermine-Topiramate, Placebo.
What is the best way to schedule an appointment with Siddharth Singh, MD?
Apply for one of the trials that Siddharth Singh, MD is conducting.
What is the office address of Siddharth Singh, MD?
The office of Siddharth Singh, MD is located at: UC San Diego Health, La Jolla, California 92037 United States. This is the address for their practice at the UC San Diego Health.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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