Dr. Sean Nestor, Dr
Claim this profileSunnybrook Health Sciences Centre
Studies Depression
Studies Depression Treatment
3 reported clinical trials
4 drugs studied
Affiliated Hospitals
Clinical Trials Sean Nestor, Dr is currently running
Theta-Burst Stimulation
for Post-Concussion Syndrome
TMS has been safely and reliably delivered at the Harquail Centre for over 5 years, with a primary focus on conventional rTMS protocols for treatment-resistant depression. Recently, the investgator team has gained the capability to deliver sham-controlled intermittent theta-burst stimulation (iTBS) rTMS. Unlike conventional high frequency rTMS, which was used in the previous sham-controlled rTMS PCS pilot study, iTBS is a patterned form of stimulation that recapitulates endogenous activity patterns of neural circuits pairing gamma frequency (50Hz) burst pulses coupled in a theta frequency rhythm (5Hz).12 iTBS delivers 600 pulses in just over 3 minutes with similar or greater effects on neural plasticity compared to conventional rTMS (taking over 30-45 minutes) and similar tolerability and efficacy in trials of depression. Furthermore, novel accelerated iTBS protocols stimulating the left dorsolateral prefrontal cortex (dlPFC) over 8-10 treatments, 50 minutes apart over a 5 day interval has recently demonstrated robust efficacy in depression and received recent FDA approval. Thus, accelerated iTBS can be delivered in a single week of treatment compared to 6 weeks with conventional rTMS methods. Finally, the investigators recently acquired the technology to integrate MRI neuroimage-guided stimulation, which would allow to target specific brain regions/networks implicated in PCS at high spatial resolution. No studies to date have investigated image-guided accelerated iTBS rTMS for the treatment of PCS.
Recruiting0 awards N/A
Psilocybin
for Depression
The goal of this neuroimaging clinical trial is to test whether psilocybin produces significant immediate changes in functional brain activity in networks associated with mood regulation and depression compared to placebo in patients with depression. The trial aims to determine if psilocybin: 1. Changes connectivity within brain networks associated with mood and depression 2. Changes blood flow in brain regions associated with mood and depression Participants will be attend two treatment sessions where they receive an oral medication and supportive psychotherapy. At each session, participants will undergo an MRI scan after drug administration but prior to psychotherapy. Participants will be randomly to assigned to one of two groups that will receive, 1) microcrystalline cellulose (25mg) at the first visit and psilocybin (25mg) at the second visit, or 2) psilocybin (25mg) at both visits, respectively. Differences between groups will be compared to understand what effects on brain activity are specific to psilocybin.
Recruiting1 award Phase 2
More about Sean Nestor, Dr
Clinical Trial Related1 year of experience running clinical trials · Led 3 trials as a Principal Investigator · 3 Active Clinical TrialsTreatments Sean Nestor, Dr has experience with
- Niacin
- Psilocybin
- Accelerated, Theta-burst Stimulation
- Repetitive Transcranial Magnetic Stimulation
Breakdown of trials Sean Nestor, Dr has run
Depression
Depression Treatment
Major Depression
Post-Concussion Syndrome
Postprandial Fullness Syndrome
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Sean Nestor, Dr specialize in?
Sean Nestor, Dr focuses on Depression and Depression Treatment. In particular, much of their work with Depression has involved treating patients, or patients who are undergoing treatment.
Is Sean Nestor, Dr currently recruiting for clinical trials?
Yes, Sean Nestor, Dr is currently recruiting for 3 clinical trials in Toronto Ontario. If you're interested in participating, you should apply.
Are there any treatments that Sean Nestor, Dr has studied deeply?
Yes, Sean Nestor, Dr has studied treatments such as Niacin, Psilocybin, Accelerated, Theta-burst Stimulation.
What is the best way to schedule an appointment with Sean Nestor, Dr?
Apply for one of the trials that Sean Nestor, Dr is conducting.
What is the office address of Sean Nestor, Dr?
The office of Sean Nestor, Dr is located at: Sunnybrook Health Sciences Centre, Toronto, Ontario M4N3M5 Canada. This is the address for their practice at the Sunnybrook Health Sciences Centre.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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