Dr. Sandra Leibel
Claim this profileRady Children's at Scripps Memorial Hospital La Jolla/UCSD
Studies Pulmonary Injury
Studies Bronchopulmonary Dysplasia
2 reported clinical trials
2 drugs studied
Affiliated Hospitals
Clinical Trials Sandra Leibel is currently running
Structured CPAP Weaning
for Neonatal Respiratory Failure
Preterm neonates born at less than 30 weeks' gestation are commonly maintained on invasive or non-invasive respiratory support to facilitate gas exchange. While non-invasive respiratory support (NIS) can be gradually reduced over time as the infant grows, most weaning strategies often lead to weaning failure. This failure is evidenced by an increase in significant events such as apneas, desaturations, and/or bradycardias, increased work of breathing, or an inability to oxygenate or ventilate, resulting in escalated respiratory support. Although the optimal approach to weaning NIS remains uncertain, neonatal units that delay Continuous Positive Airway Pressure (CPAP) weaning until 32-34 weeks corrected gestational age exhibit lower rates of chronic lung disease. Therefore, the investigators aim to compare the duration on respiratory support and oxygen exposure in infants born at less than 30 weeks' gestational age who undergo a structured weaning protocol that includes remaining on CPAP until at least 32-34 weeks corrected gestational age (CGA). The hypothesis posits that preterm infants following a structured weaning protocol, including maintaining CPAP until a specific gestational age, will demonstrate lower rates of weaning failure off CPAP (defined as requiring more support and/or experiencing increased stimulation events 72 hours after CPAP weaning) than those managed according to the medical team's discretion.
Recruiting1 award N/A2 criteria
PEEP Levels
for Premature Birth
Premature babies often need help immediately after birth to open their lungs to air, start breathing and keep their hearts beating. Opening their lungs can be difficult, and once open the under-developed lungs of premature babies will often collapse again between each breath. To prevent this nearly all premature babies receive some form of mechanical respiratory support to aid breathing. Common to all types of respiratory support is the delivery of a treatment called positive end-expiratory pressure, or PEEP. PEEP gives air, or a mixture of air and oxygen, to the lung between each breath to keep the lungs open and stop them collapsing. Currently, clinicians do not have enough evidence on the right amount, or level, of PEEP to give at birth. As a result, doctors around the world give different amounts (or levels) of PEEP to premature babies at birth. In this study, the Investigators will look at 2 different approaches to PEEP to help premature babies during their first breaths at birth. At the moment, the Investigators do not know if one is better than the other. One is to give the same PEEP level to the lungs. The others is to give a high PEEP level at birth when the lungs are hardest to open and then decrease the PEEP later once the lungs are opened and the baby is breathing. Very premature babies have a risk of long-term lung disease (chronic lung disease). The more breathing support a premature baby needs, the more likely the risk of developing chronic lung disease. The Investigators want to find out whether one method of opening the baby's lungs at birth results in them needing less breathing support. This research has been initiated by a group of doctors from Australia, the Netherlands and the USA, all who look after premature babies.
Recruiting1 award N/A3 criteria
More about Sandra Leibel
Clinical Trial Related2 years of experience running clinical trials · Led 2 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Sandra Leibel has experience with
- Positive End-Expiratory Pressure (PEEP)
- Standardized/structured CPAP Weaning Protocol
Breakdown of trials Sandra Leibel has run
Pulmonary Injury
Bronchopulmonary Dysplasia
Premature Birth
Lung Injury
Neonatal Respiratory Failure
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Sandra Leibel specialize in?
Sandra Leibel focuses on Pulmonary Injury and Bronchopulmonary Dysplasia. In particular, much of their work with Pulmonary Injury has involved treating patients, or patients who are undergoing treatment.
Is Sandra Leibel currently recruiting for clinical trials?
Yes, Sandra Leibel is currently recruiting for 2 clinical trials in San Diego California. If you're interested in participating, you should apply.
Are there any treatments that Sandra Leibel has studied deeply?
Yes, Sandra Leibel has studied treatments such as Positive End-Expiratory Pressure (PEEP), Standardized/structured CPAP weaning protocol.
What is the best way to schedule an appointment with Sandra Leibel?
Apply for one of the trials that Sandra Leibel is conducting.
What is the office address of Sandra Leibel?
The office of Sandra Leibel is located at: Rady Children's at Scripps Memorial Hospital La Jolla/UCSD, San Diego, California 92037 United States. This is the address for their practice at the Rady Children's at Scripps Memorial Hospital La Jolla/UCSD.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
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