Dr. Robin L Aupperle, PhD
Claim this profileLaureate Institute for Brain Research
Studies Anxiety Disorders
Studies Depression
4 reported clinical trials
9 drugs studied
Affiliated Hospitals
Clinical Trials Robin L Aupperle, PhD is currently running
Amplification of Positivity + Cognitive Behavioral Therapy
for Alcoholism
The proposed study consists of two phases. During Phase 1, the investigators will recruit a small sample of participants to complete a psychosocial intervention termed Amplification of Positivity (AMP) for individuals experiencing comorbid depression or anxiety disorders and alcohol use disorder (AMP-A). These participants will be asked to provide both qualitative and quantitative input about the AMP-A intervention. Based on their input and clinician input, the AMP-A manual will be modified for use in Phase 2. The goal is to recruit up to 20 participants in order to ensure there will be at least 8 participants who complete all sessions of AMP-A. Phase 2 is a randomized clinical trial (RCT) protocol in which individuals experiencing comorbid depression or anxiety disorders and alcohol use disorder will be randomized to complete AMP-A or an evidence-based cognitive-behavioral therapy (CBT) intervention. Up to 100 participants will be recruited in order to reach a target of N=60. Assessed outcomes will include participant acceptability and completion rates, participant compliance with the intervention, positive and negative affect, substance use- and depression and anxiety-related symptom severity, functional disability, and neural reactivity to reward and alcohol cues during functional magnetic resonance imaging (fMRI).
Recruiting1 award N/A6 criteria
Behavioral Therapies
for Anxiety and Depression
Depression and anxiety disorders rank in the top ten causes of years lived with disability. Less than 50% of patients experiencing long-lasting improvements to current gold-standard treatments. Two gold-standard behavioral interventions include behavioral activation, focused on enhancing approach behavior towards meaningful activities, and exposure-based therapy, focused on decreasing avoidance and challenging negative expectations. While these interventions have divergent treatment targets, there is little knowledge to inform which strategies should be used in the frequent case of comorbid anxiety and depression. Approach-avoidance decision-making paradigms focus on assessing responses when faced with potential rewards and threats, tapping into processes important for both anxiety and depression as well as behavioral activation and exposure-based therapy. For this study, investigators will recruit individuals reporting both anxiety and depression symptoms and randomize them to one of three different interventions: (1) behavioral activation, (2) exposure-based therapy, and a non-specific therapy approach (3) supportive therapy. Participants will complete clinical, self-report, behavioral, and functional magnetic resonance imaging (fMRI) assessments before and after therapy. Investigators will use a computational approach to model factors that may influence one's behavior during approach-avoidance decision-making, including drives to avoid threat versus approach reward and confidence versus uncertainty in one's decisions. This project will accomplish the following aims (1) Determine how changes in brain and behavior responses during approach-avoidance conflict relate to changes in mental health symptoms with the different therapy approaches, (2) Determine the degree to which baseline brain and behavior responses during approach-avoidance conflict predict response to the different therapy approaches, above and beyond the influence of demographics and baseline symptom severity. In addition, by including peripheral blood draws and measures of grace matter volume, the project will also accomplish the following aims: (1) Determine whether kynrenine metabolites measures peripherally may be beneficial as a biomarker of treatment response and (2) determine whether there is an association between change in kynurenine metabolites and changes in gray matter volume with treatment. Results will enhance understanding of how different psychotherapy approaches (behavioral activation, exposure-based therapy) may impact brain responses and decisions when faces with potential reward versus threat and approach versus avoidance drives. In addition, results will have important implications concerning the potential for a more personalized approach to psychotherapy, enhancing knowledge of which types of therapy strategies may be most beneficial for which individuals.
Recruiting1 award N/A
More about Robin L Aupperle, PhD
Clinical Trial Related2 years of experience running clinical trials · Led 4 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Robin L Aupperle, PhD has experience with
- Amplification Of Positivity Therapy
- Cognitive Behavioral Therapy
- Behavioral Activation
- Exposure-based Therapy
- Supportive Therapy
- Amplification Of Positivity Training
Breakdown of trials Robin L Aupperle, PhD has run
Anxiety Disorders
Depression
Anxiety
Alcohol-Related Intimate Partner Violence
Other Doctors you might be interested in
Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Robin L Aupperle, PhD specialize in?
Robin L Aupperle, PhD focuses on Anxiety Disorders and Depression. In particular, much of their work with Anxiety Disorders has involved treating patients, or patients who are undergoing treatment.
Is Robin L Aupperle, PhD currently recruiting for clinical trials?
Yes, Robin L Aupperle, PhD is currently recruiting for 2 clinical trials in Tulsa Oklahoma. If you're interested in participating, you should apply.
Are there any treatments that Robin L Aupperle, PhD has studied deeply?
Yes, Robin L Aupperle, PhD has studied treatments such as Amplification of Positivity Therapy, Cognitive Behavioral Therapy, Behavioral Activation.
What is the best way to schedule an appointment with Robin L Aupperle, PhD?
Apply for one of the trials that Robin L Aupperle, PhD is conducting.
What is the office address of Robin L Aupperle, PhD?
The office of Robin L Aupperle, PhD is located at: Laureate Institute for Brain Research, Tulsa, Oklahoma 74008 United States. This is the address for their practice at the Laureate Institute for Brain Research.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.