Rene McNall-Knapp, MD | OU Health

Dr. Rene Y. McNall-Knapp

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University of Oklahoma Health Sciences Center

Expert in Cancer
Expert in Brain Tumor
72 reported clinical trials
127 drugs studied

About Rene Y. McNall-Knapp

Education:

  • Obtained MD (Doctor of Medicine) from the University of Oklahoma College of Medicine, 2008.

  • Completed Residency in Internal Medicine at the University of Oklahoma Health Sciences Center, 2011.

  • Finished Fellowship in Hematology/Oncology at the University of Oklahoma Health Sciences Center, 2014.

Experience:

  • Currently serves as an Assistant Professor in the Department of Medicine, Division of Hematology/Oncology, at the University of Oklahoma Health Sciences Center.

Area of expertise

1

Cancer

Global Leader

Rene Y. McNall-Knapp has run 23 trials for Cancer. Some of their research focus areas include:

Stage IV
Stage I
Stage II
2

Brain Tumor

Global Leader

Rene Y. McNall-Knapp has run 20 trials for Brain Tumor. Some of their research focus areas include:

Stage I
Stage II
Stage IV

Affiliated Hospitals

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University Of Oklahoma Health Sciences Center

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Oklahoma University Cancer Institute

Clinical Trials Rene Y. McNall-Knapp is currently running

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Selumetinib vs. Chemotherapy

for Brain Cancer

This trial is comparing a new drug, selumetinib, with standard chemotherapy to treat patients with a specific type of brain tumor. The patients do not have a certain genetic mutation and are not affected by a genetic disorder. Selumetinib works by blocking enzymes needed for tumor growth, while the standard drugs kill or stop tumor cells from dividing.

Recruiting

2 awards

Phase 3

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Inotuzumab Ozogamicin

for Acute Lymphoblastic Leukemia

This phase III trial studies whether inotuzumab ozogamicin added to post-induction chemotherapy for patients with High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) improves outcomes. This trial also studies the outcomes of patients with mixed phenotype acute leukemia (MPAL), and B-lymphoblastic lymphoma (B-LLy) when treated with ALL therapy without inotuzumab ozogamicin. Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a type of chemotherapy called calicheamicin. Inotuzumab attaches to cancer cells in a targeted way and delivers calicheamicin to kill them. Other drugs used in the chemotherapy regimen, such as cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine, vincristine, and pegaspargase or calaspargase pegol work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial will also study the outcomes of patients with mixed phenotype acute leukemia (MPAL) and disseminated B lymphoblastic lymphoma (B-LLy) when treated with high-risk ALL chemotherapy. The overall goal of this study is to understand if adding inotuzumab ozogamicin to standard of care chemotherapy maintains or improves outcomes in High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL). The first part of the study includes the first two phases of therapy: Induction and Consolidation. This part will collect information on the leukemia, as well as the effects of the initial treatment, to classify patients into post-consolidation treatment groups. On the second part of this study, patients with HR B-ALL will receive the remainder of the chemotherapy cycles (interim maintenance I, delayed intensification, interim maintenance II, maintenance), with some patients randomized to receive inotuzumab. The patients that receive inotuzumab will not receive part of delayed intensification. Other aims of this study include investigating whether treating both males and females with the same duration of chemotherapy maintains outcomes for males who have previously been treated for an additional year compared to girls, as well as to evaluate the best ways to help patients adhere to oral chemotherapy regimens. Finally, this study will be the first to track the outcomes of subjects with disseminated B-cell Lymphoblastic Leukemia (B-LLy) or Mixed Phenotype Acute Leukemia (MPAL) when treated with B-ALL chemotherapy.

Recruiting

2 awards

Phase 3

More about Rene Y. McNall-Knapp

Clinical Trial Related

8 years of experience running clinical trials · Led 72 trials as a Principal Investigator · 23 Active Clinical Trials

Treatments Rene Y. McNall-Knapp has experience with

  • Radiation Therapy
  • Cyclophosphamide
  • Nivolumab
  • Etoposide
  • Doxorubicin Hydrochloride
  • Vincristine Sulfate

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