Dr. Paula Klein, MD
Claim this profileMount Sinai Beth Israel Comprehensive Cancer Center West
Studies Breast Cancer
Studies Breast cancer
6 reported clinical trials
14 drugs studied
Area of expertise
1Breast Cancer
Stage IV
ER positive
HER2 negative
2Breast Cancer
Stage IV
ER positive
PR positive
Affiliated Hospitals
Clinical Trials Paula Klein, MD is currently running
Durvalumab + Chemotherapy
for Breast Cancer
This phase III trial compares the addition of an immunotherapy drug (durvalumab) to usual chemotherapy versus usual chemotherapy alone in treating patients with MammaPrint High 2 Risk (MP2) stage II-III hormone receptor positive, HER2 negative breast cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as paclitaxel, doxorubicin, and cyclophosphamide work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. There is some evidence from previous clinical trials that people who have a MammaPrint High 2 Risk result may be more likely to respond to chemotherapy and immunotherapy. Adding durvalumab to usual chemotherapy may be able to prevent the cancer from returning for patients with MP2 stage II-III hormone receptor positive, HER2 negative breast cancer.
Recruiting2 awards Phase 340 criteria
DNA-Guided Adjuvant Therapy
for Breast Cancer
A randomized, Phase II trial of circulating tumor DNA-guided second line Adjuvant therapy for high Residual risk, Estrogen Receptor positive, HER-2 negative breast cancer (DARE)
Recruiting1 award Phase 29 criteria
More about Paula Klein, MD
Clinical Trial Related1 year of experience running clinical trials · Led 6 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Paula Klein, MD has experience with
- Paclitaxel
- Palbociclib
- Pertuzumab
- Trastuzumab
- Anastrozole
- Avelumab
Breakdown of trials Paula Klein, MD has run
Breast Cancer
Breast cancer
Skin Cancer
Endocrine Breast Disease
Breast Disease
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