Noam Y. Harel, MD, PhD | American ...

Dr. Noam Y Harel, MD PhD

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James J. Peters VA Medical Center, Bronx, NY

Studies Spinal Cord Injury
Studies Quadriplegia
5 reported clinical trials
12 drugs studied

Area of expertise

1Spinal Cord Injury
Noam Y Harel, MD PhD has run 4 trials for Spinal Cord Injury. Some of their research focus areas include:
C1
C2
C3
2Quadriplegia
Noam Y Harel, MD PhD has run 2 trials for Quadriplegia.

Affiliated Hospitals

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James J. Peters VA Medical Center, Bronx, NY
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Bronx Veterans Medical Research Foundation, Inc

Clinical Trials Noam Y Harel, MD PhD is currently running

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Spinal Cord Stimulation

for Spinal Cord Injury

Spinal cord associative plasticity (SCAP) is a combined cortical and spinal electrical stimulation technique developed to induce recovery of arm and hand function in spinal cord injury. The proposed study will advance understanding of SCAP, which is critical to its effective translation to human therapy. The purpose of the study is to: 1. Determine whether signaling through the spinal cord to the muscles can be strengthened by electrical stimulation. 2. Improve our understanding of the spinal cord and how it produces movement. 3. Determine whether spinal surgery to relieve pressure on the spinal cord can improve its function. Aim 1 is designed to advance mechanistic understanding of spinal cord associative plasticity (SCAP). Aim 2 will determine whether SCAP increases spinal cord excitability after the period of repetitive pairing. In rats, SCAP augments muscle activation for hours after just 5 minutes of paired stimuli. Whereas Aims 1 and 2 focused on the effects of paired stimulation in the context of uninjured spinal cord, Aim 3 assesses whether paired stimulation can be effective across injured cord segments. Aim 3 will incorporate the experiments from Aim 1 and 2 but in people with SCI, either traumatic or pre-operative patients with myelopathy in non-invasive experiments, or targeting myelopathic segments in intraoperative segments.
Recruiting1 award Phase < 19 criteria
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SCAP and Hand Exercises

for ALS

Veterans are at higher risk than non-Veterans of falling ill with amyotrophic lateral sclerosis (ALS). The investigators have shown that synchronized stimulation over the brain and cervical spinal cord can temporarily strengthen weakened nerve circuits between the brain and hand muscles in people with ALS. The current proposal will take the next step of individualizing this intervention, then applying it repetitively in an attempt to achieve direct clinical benefit on hand strength and function. Following an initial 2-3 month period of optimizing the intervention for each individual, the investigators will compare the effects of two-week programs of paired brain-spinal stimulation with or without hand exercises.
Recruiting1 award N/A

More about Noam Y Harel, MD PhD

Clinical Trial Related1 year of experience running clinical trials · Led 5 trials as a Principal Investigator · 2 Active Clinical Trials
Treatments Noam Y Harel, MD PhD has experience with
  • Robotic Gait Training
  • Transspinal Stimulation
  • Spinal Cord Associative Plasticity (SCAP)
  • Upper Extremity Task-oriented Exercise
  • Intraoperative Pairing Of Cortical And Spinal Stimulation
  • Intraoperative Repeated Pairing Of Cortical And Spinal Stimulation (SCAP)

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